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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM50343246'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50343246
PNG
(CHEMBL1773572 | N-(6-(2-(2-Phenylpropan-2-ylamino)...)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NC(C)(C)c2ccccc2)n1
Show InChI InChI=1S/C22H21N5OS/c1-14(28)24-21-26-18-10-9-15(13-19(18)29-21)17-11-12-23-20(25-17)27-22(2,3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H,23,25,27)(H,24,26,28)
PDB
MMDB

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Article
PubMed
24n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha expressed in Sf9 cells


J Med Chem 54: 1789-811 (2011)


Article DOI: 10.1021/jm1014605
BindingDB Entry DOI: 10.7270/Q2TH8N1K
More data for this
Ligand-Target Pair