Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5 (Homo sapiens (Human)) | BDBM25072 (4-[2-(4-methylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.83 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... | Bioorg Med Chem Lett 17: 756-60 (2007) Article DOI: 10.1016/j.bmcl.2006.10.080 BindingDB Entry DOI: 10.7270/Q2NS0S6N | |||||||||||
More data for this Ligand-Target Pair |