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Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4-kinase alpha' and Ligand = 'BDBM50448083'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4-kinase alpha


(Homo sapiens (Human))		BDBM50448083
PNG
(CHEMBL3121325)
Show SMILES CCn1c(N)nc2ccc(cc2c1=O)-c1cnc(OC)c(c1)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C22H19F2N5O4S/c1-3-29-21(30)15-8-12(4-6-17(15)27-22(29)25)13-9-19(20(33-2)26-11-13)34(31,32)28-18-7-5-14(23)10-16(18)24/h4-11,28H,3H2,1-2H3,(H2,25,27)
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Article
PubMed
n/an/a 40n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...

J Med Chem 57: 2091-106 (2014)


Article DOI: 10.1021/jm400781h
BindingDB Entry DOI: 10.7270/Q2WH2RG0
More data for this
Ligand-Target Pair