Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phospholipase D2 (Homo sapiens (Human)) | BDBM87245 (CHEMBL492797 | ML272 | N-(2-(4-(2-Oxo-2,3-dihydro-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 225 | n/a | n/a | n/a | n/a | n/a | 37 |
University of Massachusetts Boston | Assay Description PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions... | Chem Biol Drug Des 84: 270-81 (2014) Article DOI: 10.1111/cbdd.12319 BindingDB Entry DOI: 10.7270/Q2HT2N05 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D2 (Homo sapiens (Human)) | BDBM87245 (CHEMBL492797 | ML272 | N-(2-(4-(2-Oxo-2,3-dihydro-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description In vitro PLD activity is measured with an exogenous substrate assay as previously described (Brown, H. A. et al. (1993) Cell 75:1137-1144). Briefly, ... | US Patent US9453017 (2016) BindingDB Entry DOI: 10.7270/Q29K495R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D2 (Homo sapiens (Human)) | BDBM87245 (CHEMBL492797 | ML272 | N-(2-(4-(2-Oxo-2,3-dihydro-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 241 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt Specialized Chemistry Center Curated by PubChem BioAssay | Assay Description Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2X34W1R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D2 (Homo sapiens (Human)) | BDBM87245 (CHEMBL492797 | ML272 | N-(2-(4-(2-Oxo-2,3-dihydro-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of GFP-labelled human PLD2 HEK293 cells | Bioorg Med Chem Lett 19: 1916-20 (2009) Article DOI: 10.1016/j.bmcl.2009.02.057 BindingDB Entry DOI: 10.7270/Q2VM4C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D2 (Homo sapiens (Human)) | BDBM87245 (CHEMBL492797 | ML272 | N-(2-(4-(2-Oxo-2,3-dihydro-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description The ability of representative disclosed to block influenza infection was assessed in a cell-based assay using A549 human epithelial cells (ATCC CCL-1... | US Patent US9453017 (2016) BindingDB Entry DOI: 10.7270/Q29K495R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D2 (Homo sapiens (Human)) | BDBM87245 (CHEMBL492797 | ML272 | N-(2-(4-(2-Oxo-2,3-dihydro-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 384 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt Specialized Chemistry Center Curated by PubChem BioAssay | Assay Description Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q21R6P4V | |||||||||||
More data for this Ligand-Target Pair |