Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92482 (CDE-008 | US9120744, CDE-008) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 370 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92482 (CDE-008 | US9120744, CDE-008) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 23 | n/a | n/a | n/a | 5.0 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92482 (CDE-008 | US9120744, CDE-008) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 23 | n/a | n/a | n/a | 7.8 | 23 |
University of Michigan | Assay Description Enzyme activity assay using human and murine PAI-1. | J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC | |||||||||||
More data for this Ligand-Target Pair |