Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Presenilin-1 (Homo sapiens (Human)) | BDBM50114789 (CHEMBL3609747) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated for 16 to 1... | Citation and Details Article DOI: 10.1039/d0md00196a BindingDB Entry DOI: 10.7270/Q2V69P6T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50114789 (CHEMBL3609747) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 67 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of gamma-secretase in human H4 cells expressing human APP751 assessed as inhibition of amyloid beta 42 production after 16 to 18 hrs by EL... | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair |