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Found 1 hit Enz. Inhib. hit(s) with Target = 'Proprotein convertase subtilisin/kexin type 6' and Ligand = 'BDBM50399754'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proprotein convertase subtilisin/kexin type 6


(Homo sapiens (Human))		BDBM50399754
PNG
(CHEMBL2179836)
Show SMILES [#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#8])=O |r|
Show InChI InChI=1S/C37H69N15O13/c38-15-3-1-7-21(47-29(58)20(40)11-13-27(54)55)30(59)50-24(12-14-28(56)57)33(62)48-23(9-5-17-45-36(41)42)32(61)52-26(19-53)34(63)49-22(8-2-4-16-39)31(60)51-25(35(64)65)10-6-18-46-37(43)44/h20-26,53H,1-19,38-40H2,(H,47,58)(H,48,62)(H,49,63)(H,50,59)(H,51,60)(H,52,61)(H,54,55)(H,56,57)(H,64,65)(H4,41,42,45)(H4,43,44,46)/t20-,21-,22-,23-,24-,25-,26-/m0/s1
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Similars
Article
PubMed
 1.10n/an/an/an/an/an/a6.5n/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...

J Med Chem 55: 10501-11 (2012)


Article DOI: 10.1021/jm3011178
BindingDB Entry DOI: 10.7270/Q2NV9KDZ
More data for this
Ligand-Target Pair