| Reaction Details |
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 | Report a problem with these data |
| Target | Proprotein convertase subtilisin/kexin type 6 |
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| Ligand | BDBM50399754 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_877191 (CHEMBL2187699) |
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| pH | 6.5±n/a |
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| Ki | 1.1±n/a nM |
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| Comments | extracted |
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| Citation |  Levesque, C; Fugère, M; Kwiatkowska, A; Couture, F; Desjardins, R; Routhier, S; Moussette, P; Prahl, A; Lammek, B; Appel, JR; Houghten, RA; D'Anjou, F; Dory, YL; Neugebauer, W; Day, R The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells. J Med Chem55:10501-11 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proprotein convertase subtilisin/kexin type 6 |
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| Name: | Proprotein convertase subtilisin/kexin type 6 |
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| Synonyms: | PACE4 | PCSK6 | PCSK6_HUMAN | Subtilisin/kexin type 6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 106442.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1290742 |
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| Residue: | 969 |
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| Sequence: | MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL
GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC
VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS
ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
CDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQF
CCRTCLLAG
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| BDBM50399754 |
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| n/a |
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| Name | BDBM50399754 |
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| Synonyms: | CHEMBL2179836 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H69N15O13 |
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| Mol. Mass. | 932.0365 |
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| SMILES | [#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#8])=O |r| |
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| Structure | 
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