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Found 1 hit Enz. Inhib. hit(s) with Target = 'Proprotein convertase subtilisin/kexin type 6' and Ligand = 'BDBM50399760'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proprotein convertase subtilisin/kexin type 6


(Homo sapiens (Human))		BDBM50399760
PNG
(CHEMBL2179427)
Show SMILES [#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#8])=O |r|
Show InChI InChI=1S/C39H67N15O10/c40-16-6-4-12-24(32(58)51-25(13-5-7-17-41)34(60)53-27(37(63)64)15-9-19-48-39(45)46)50-33(59)26(14-8-18-47-38(43)44)52-36(62)29(21-31(56)57)54-35(61)28(49-30(55)22-42)20-23-10-2-1-3-11-23/h1-3,10-11,24-29H,4-9,12-22,40-42H2,(H,49,55)(H,50,59)(H,51,58)(H,52,62)(H,53,60)(H,54,61)(H,56,57)(H,63,64)(H4,43,44,47)(H4,45,46,48)/t24-,25-,26-,27-,28-,29-/m0/s1
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Similars
Article
PubMed
>1.00E+3n/an/an/an/an/an/a6.5n/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...

J Med Chem 55: 10501-11 (2012)


Article DOI: 10.1021/jm3011178
BindingDB Entry DOI: 10.7270/Q2NV9KDZ
More data for this
Ligand-Target Pair