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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Prostaglandin E2 receptor EP4 subtype' and Ligand = 'BDBM50333727'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50333727
PNG
(3-(4-((N-(1-(2-methoxyphenyl)cyclopropanecarbonyl)...)
Show SMILES COc1ccccc1C1(CC1)C(=O)NS(=O)(=O)Cc1ccc(cc1)-c1c(sc2c(C)cc(C)cc12)C(=O)N(C)C
Show InChI InChI=1S/C31H32N2O5S2/c1-19-16-20(2)27-23(17-19)26(28(39-27)29(34)33(3)4)22-12-10-21(11-13-22)18-40(36,37)32-30(35)31(14-15-31)24-8-6-7-9-25(24)38-5/h6-13,16-17H,14-15,18H2,1-5H3,(H,32,35)
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0.330n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity to EP4 receptor


Bioorg Med Chem Lett 21: 734-7 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.118
BindingDB Entry DOI: 10.7270/Q22N52JP
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50333727
PNG
(3-(4-((N-(1-(2-methoxyphenyl)cyclopropanecarbonyl)...)
Show SMILES COc1ccccc1C1(CC1)C(=O)NS(=O)(=O)Cc1ccc(cc1)-c1c(sc2c(C)cc(C)cc12)C(=O)N(C)C
Show InChI InChI=1S/C31H32N2O5S2/c1-19-16-20(2)27-23(17-19)26(28(39-27)29(34)33(3)4)22-12-10-21(11-13-22)18-40(36,37)32-30(35)31(14-15-31)24-8-6-7-9-25(24)38-5/h6-13,16-17H,14-15,18H2,1-5H3,(H,32,35)
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5.20n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity to EP4 receptor in presence of 10% HSA


Bioorg Med Chem Lett 21: 734-7 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.118
BindingDB Entry DOI: 10.7270/Q22N52JP
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50333727
PNG
(3-(4-((N-(1-(2-methoxyphenyl)cyclopropanecarbonyl)...)
Show SMILES COc1ccccc1C1(CC1)C(=O)NS(=O)(=O)Cc1ccc(cc1)-c1c(sc2c(C)cc(C)cc12)C(=O)N(C)C
Show InChI InChI=1S/C31H32N2O5S2/c1-19-16-20(2)27-23(17-19)26(28(39-27)29(34)33(3)4)22-12-10-21(11-13-22)18-40(36,37)32-30(35)31(14-15-31)24-8-6-7-9-25(24)38-5/h6-13,16-17H,14-15,18H2,1-5H3,(H,32,35)
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16n/an/an/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Ratio of Ki for EP4 receptor to EP4 receptor in presence of 10% HSA


Bioorg Med Chem Lett 21: 734-7 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.118
BindingDB Entry DOI: 10.7270/Q22N52JP
More data for this
Ligand-Target Pair