BindingDB PrimarySearch

Found 14 hits Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 2' and Ligand = 'BDBM50174201'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Dallas Department of Veterans Affairs Medical Center Curated by PDSP K_i Database									Am J Med 104: 413-21 (1998) Article DOI: 10.1016/s0002-9343(98)00091-6 BindingDB Entry DOI: 10.7270/Q2F18X97
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
St. Bartholomew's and the Royal London School of Medicine and Dentistry Curated by PDSP K_i Database									Proc Natl Acad Sci U S A 96: 7563-8 (1999) Article DOI: 10.1073/pnas.96.13.7563 BindingDB Entry DOI: 10.7270/Q21G0JT4
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
St. Bartholomew's and the Royal London School of Medicine and Dentistry Curated by PDSP K_i Database									Proc Natl Acad Sci U S A 96: 7563-8 (1999) Article DOI: 10.1073/pnas.96.13.7563 BindingDB Entry DOI: 10.7270/Q21G0JT4
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 290: 551-60 (1999) BindingDB Entry DOI: 10.7270/Q2S18110
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 296: 558-66 (2001) BindingDB Entry DOI: 10.7270/Q2QR4VPJ
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human recombinant COX2 by colorimetric analysis				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112439 BindingDB Entry DOI: 10.7270/Q2057KNJ
TBA					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Alexandria University Curated by ChEMBL					Assay Description Inhibition of human recombinant COX2 catalytic activity using arachidonic acid as substrate pre-incubated for 10 mins followed by substrate addition ...				Eur J Med Chem 167: 562-582 (2019) Article DOI: 10.1016/j.ejmech.2019.02.034 BindingDB Entry DOI: 10.7270/Q2DN48FJ
Alexandria University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Alexandria University Curated by ChEMBL					Assay Description Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha production using arachidonic acid as substrate by colorimetric method				Eur J Med Chem 144: 635-650 (2018) Article DOI: 10.1016/j.ejmech.2017.12.065 BindingDB Entry DOI: 10.7270/Q2FX7D4C
Alexandria University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
Cairo University Curated by ChEMBL					Assay Description Inhibition of human recombinant COX-2 by EIA method				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111693 BindingDB Entry DOI: 10.7270/Q2988B9C
Cairo University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition by color...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113457 BindingDB Entry DOI: 10.7270/Q2VM4H26
TBA					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
Assiut University Curated by ChEMBL					Assay Description Inhibition of human recombinant COX2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2...				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115403 BindingDB Entry DOI: 10.7270/Q2QJ7MVZ
Assiut University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Ovis aries (Sheep))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Mansoura Curated by ChEMBL					Assay Description Inhibition of ovine COX2 assessed as PGF2alpha production from PGH2 after 5 mins by enzyme immunoassay				Bioorg Med Chem 19: 3416-24 (2011) Article DOI: 10.1016/j.bmc.2011.04.027 BindingDB Entry DOI: 10.7270/Q2JM29ZT
University of Mansoura Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Ovis aries (Sheep))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Mansoura Curated by ChEMBL					Assay Description Inhibition of ovine COX2 by enzyme immuno assay				Bioorg Med Chem 20: 3306-16 (2012) Article DOI: 10.1016/j.bmc.2012.03.044 BindingDB Entry DOI: 10.7270/Q2MK6DWZ
University of Mansoura Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Ovis aries (Sheep))	BDBM50174201 (ARTHROTEC \| GP 45840 \| SOLARAZE \| Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
King Saud University Curated by ChEMBL					Assay Description Inhibition of ovine COX2-mediated prostaglandin alpha production by enzyme immuno assay				Bioorg Med Chem Lett 23: 2601-5 (2013) Article DOI: 10.1016/j.bmcl.2013.02.107 BindingDB Entry DOI: 10.7270/Q2SJ1PHN
King Saud University Curated by ChEMBL					More data for this Ligand-Target Pair