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Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50084824'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50084824
PNG
(4-Nitro-2-(2,4,5,7-tetranitro-fluoren-9-ylidenemet...)
Show SMILES [#8]-c1ccc(cc1\[#6]=[#6]-1\c2cc(cc(c2-c2c-1cc(cc2-[#7+](-[#8-])=O)-[#7+](-[#8-])=O)-[#7+](-[#8-])=O)-[#7+](-[#8-])=O)-[#7+](-[#8-])=O
Show InChI InChI=1S/C20H9N5O11/c26-18-2-1-10(21(27)28)3-9(18)4-13-14-5-11(22(29)30)7-16(24(33)34)19(14)20-15(13)6-12(23(31)32)8-17(20)25(35)36/h1-8,26H
PDB

KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



Mayo Medical School and Mayo Clinic

Curated by ChEMBL


Assay Description
In vitro inhibition of Farnesyltransferase (FT) by using FT [3H]-SPA kit.

J Med Chem 43: 401-8 (2000)


BindingDB Entry DOI: 10.7270/Q28W3F0K
More data for this
Ligand-Target Pair