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Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein mono-ADP-ribosyltransferase PARP6' and Ligand = 'BDBM50499822'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein mono-ADP-ribosyltransferase PARP6


(Homo sapiens (Human))		BDBM50499822
PNG
(CHEMBL3740897)
Show SMILES C[C@H]1Cn2c(CN1C(=O)c1cccc(c1)C(F)(F)c1n[nH]c(=O)c3ccccc13)nnc2C(C)(F)F |r|
Show InChI InChI=1S/C24H20F4N6O2/c1-13-11-34-18(29-32-22(34)23(2,25)26)12-33(13)21(36)14-6-5-7-15(10-14)24(27,28)19-16-8-3-4-9-17(16)20(35)31-30-19/h3-10,13H,11-12H2,1-2H3,(H,31,35)/t13-/m0/s1
KEGG

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 83n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of full length human PARP6 expressed in a Baculovirus infected Sf9 insect cells using activated DNA as substrate after 1 hr by streptavidi...

Bioorg Med Chem Lett 25: 5743-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.079
BindingDB Entry DOI: 10.7270/Q2WH2T0J
More data for this
Ligand-Target Pair