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Found 1 hit Enz. Inhib. hit(s) with Target = 'Rap guanine nucleotide exchange factor 4' and Ligand = 'BDBM50425554'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Rap guanine nucleotide exchange factor 4


(Homo sapiens (Human))		BDBM50425554
PNG
(CHEMBL2313654)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)c1cc(C)c(C)cc1C
Show InChI InChI=1S/C18H22O2S/c1-11-7-15(5)18(16(6)8-11)21(19,20)17-10-13(3)12(2)9-14(17)4/h7-10H,1-6H3
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PC sid
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Article
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n/an/a 700n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay

J Med Chem 56: 952-62 (2013)


Article DOI: 10.1021/jm3014162
BindingDB Entry DOI: 10.7270/Q2D21ZX3
More data for this
Ligand-Target Pair