Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Receptor-interacting serine/threonine-protein kinase 2' and Ligand = 'BDBM50184477'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50184477 (CHEMBL3822979) Show SMILES CNc1cc(Oc2c(F)cc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2F)ccn1 Show InChI InChI=1S/C20H15F5N4O2/c1-26-17-10-14(5-6-27-17)31-18-15(21)8-13(9-16(18)22)29-19(30)28-12-4-2-3-11(7-12)20(23,24)25/h2-10H,1H3,(H,26,27)(H2,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of RIP2K in MDP-stimulated HEK-293 cells over-expressing NOD2 assessed as IL8 secretion				J Med Chem 59: 4867-80 (2016) Article DOI: 10.1021/acs.jmedchem.6b00211 BindingDB Entry DOI: 10.7270/Q2G162SQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50184477 (CHEMBL3822979) Show SMILES CNc1cc(Oc2c(F)cc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2F)ccn1 Show InChI InChI=1S/C20H15F5N4O2/c1-26-17-10-14(5-6-27-17)31-18-15(21)8-13(9-16(18)22)29-19(30)28-12-4-2-3-11(7-12)20(23,24)25/h2-10H,1H3,(H,26,27)(H2,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...				J Med Chem 59: 4867-80 (2016) Article DOI: 10.1021/acs.jmedchem.6b00211 BindingDB Entry DOI: 10.7270/Q2G162SQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50184477 (CHEMBL3822979) Show SMILES CNc1cc(Oc2c(F)cc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2F)ccn1 Show InChI InChI=1S/C20H15F5N4O2/c1-26-17-10-14(5-6-27-17)31-18-15(21)8-13(9-16(18)22)29-19(30)28-12-4-2-3-11(7-12)20(23,24)25/h2-10H,1H3,(H,26,27)(H2,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	794	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...				J Med Chem 59: 4867-80 (2016) Article DOI: 10.1021/acs.jmedchem.6b00211 BindingDB Entry DOI: 10.7270/Q2G162SQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50184477 (CHEMBL3822979) Show SMILES CNc1cc(Oc2c(F)cc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2F)ccn1 Show InChI InChI=1S/C20H15F5N4O2/c1-26-17-10-14(5-6-27-17)31-18-15(21)8-13(9-16(18)22)29-19(30)28-12-4-2-3-11(7-12)20(23,24)25/h2-10H,1H3,(H,26,27)(H2,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of RIP2K in Pam2CSK4-stimulated HEK-293 cells over-expressing TLR2 assessed as IL8 secretion				J Med Chem 59: 4867-80 (2016) Article DOI: 10.1021/acs.jmedchem.6b00211 BindingDB Entry DOI: 10.7270/Q2G162SQ
					More data for this Ligand-Target Pair