Found 5 hits Enz. Inhib. hit(s) with Target = 'Renin' and Ligand = 'BDBM149462' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Renin
(Homo sapiens (Human)) | BDBM149462
(US8975252, 39)Show SMILES COCCCn1cc(CN(C2CC2)C(=O)[C@H]2CNCCO2)c2ccccc12 |r| Show InChI InChI=1S/C21H29N3O3/c1-26-11-4-10-23-14-16(18-5-2-3-6-19(18)23)15-24(17-7-8-17)21(25)20-13-22-9-12-27-20/h2-3,5-6,14,17,20,22H,4,7-13,15H2,1H3/t20-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00280
BindingDB Entry DOI: 10.7270/Q28K7F4S |
More data for this
Ligand-Target Pair | |
Renin
(Homo sapiens (Human)) | BDBM149462
(US8975252, 39)Show SMILES COCCCn1cc(CN(C2CC2)C(=O)[C@H]2CNCCO2)c2ccccc12 |r| Show InChI InChI=1S/C21H29N3O3/c1-26-11-4-10-23-14-16(18-5-2-3-6-19(18)23)15-24(17-7-8-17)21(25)20-13-22-9-12-27-20/h2-3,5-6,14,17,20,22H,4,7-13,15H2,1H3/t20-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00834
BindingDB Entry DOI: 10.7270/Q2JS9VH0 |
More data for this
Ligand-Target Pair | |
Renin
(Homo sapiens (Human)) | BDBM149462
(US8975252, 39)Show SMILES COCCCn1cc(CN(C2CC2)C(=O)[C@H]2CNCCO2)c2ccccc12 |r| Show InChI InChI=1S/C21H29N3O3/c1-26-11-4-10-23-14-16(18-5-2-3-6-19(18)23)15-24(17-7-8-17)21(25)20-13-22-9-12-27-20/h2-3,5-6,14,17,20,22H,4,7-13,15H2,1H3/t20-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | 37 |
Shanghai Pharmaceuticals Holding Co., Ltd.; Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
A renin substrate of synthetic peptide (Nma-KHPFH LVIHK(Dnp)-NH2) and test compound were mixed, and fluorescence intensity was assayed using a fluoro... |
US Patent US8975252 (2015)
BindingDB Entry DOI: 10.7270/Q2TB15NG |
More data for this
Ligand-Target Pair | |
Renin
(Homo sapiens (Human)) | BDBM149462
(US8975252, 39)Show SMILES COCCCn1cc(CN(C2CC2)C(=O)[C@H]2CNCCO2)c2ccccc12 |r| Show InChI InChI=1S/C21H29N3O3/c1-26-11-4-10-23-14-16(18-5-2-3-6-19(18)23)15-24(17-7-8-17)21(25)20-13-22-9-12-27-20/h2-3,5-6,14,17,20,22H,4,7-13,15H2,1H3/t20-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00280
BindingDB Entry DOI: 10.7270/Q28K7F4S |
More data for this
Ligand-Target Pair | |
Renin
(Homo sapiens (Human)) | BDBM149462
(US8975252, 39)Show SMILES COCCCn1cc(CN(C2CC2)C(=O)[C@H]2CNCCO2)c2ccccc12 |r| Show InChI InChI=1S/C21H29N3O3/c1-26-11-4-10-23-14-16(18-5-2-3-6-19(18)23)15-24(17-7-8-17)21(25)20-13-22-9-12-27-20/h2-3,5-6,14,17,20,22H,4,7-13,15H2,1H3/t20-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00834
BindingDB Entry DOI: 10.7270/Q2JS9VH0 |
More data for this
Ligand-Target Pair | |
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