Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase B-raf [V600E]' and Ligand = 'BDBM185588'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM185588 (US9156852, 59 | USRE47451, Example 59) Show SMILES CN(C)Cc1cc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)ccc1Cl Show InChI InChI=1S/C26H24ClN7OS/c1-14-4-6-18-17(21(14)33-26(35)19-12-36-23-22(19)30-13-31-24(23)28)8-9-29-25(18)32-16-5-7-20(27)15(10-16)11-34(2)3/h4-10,12-13H,11H2,1-3H3,(H,29,32)(H,33,35)(H2,28,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC Curated by PubChem BioAssay					Assay Description The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...				PubChem Bioassay (2006) BindingDB Entry DOI: 10.7270/Q2XW4N61
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM185588 (US9156852, 59 | USRE47451, Example 59) Show SMILES CN(C)Cc1cc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)ccc1Cl Show InChI InChI=1S/C26H24ClN7OS/c1-14-4-6-18-17(21(14)33-26(35)19-12-36-23-22(19)30-13-31-24(23)28)8-9-29-25(18)32-16-5-7-20(27)15(10-16)11-34(2)3/h4-10,12-13H,11H2,1-3H3,(H,29,32)(H,33,35)(H2,28,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
HANMI PHARM. CO., LTD US Patent					Assay Description The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...				US Patent US9156852 (2015) BindingDB Entry DOI: 10.7270/Q24T6H4D
					More data for this Ligand-Target Pair