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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PknB' and Ligand = 'BDBM50279720'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase PknB


(Mycobacterium tuberculosis)		BDBM50279720
PNG
(CHEMBL4177229)
Show SMILES Clc1ccc2nc(nc(Nc3cc([nH]n3)C3CC3)c2c1)-c1ccc(CC#N)cc1
Show InChI InChI=1S/C22H17ClN6/c23-16-7-8-18-17(11-16)22(26-20-12-19(28-29-20)14-5-6-14)27-21(25-18)15-3-1-13(2-4-15)9-10-24/h1-4,7-8,11-12,14H,5-6,9H2,(H2,25,26,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
 5n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...

ACS Med Chem Lett 8: 1224-1229 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00239
BindingDB Entry DOI: 10.7270/Q2183910
More data for this
Ligand-Target Pair