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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-2' and Ligand = 'BDBM50261856'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261856
PNG
(CHEMBL4071926)
Show SMILES [#6]\[#6](-[#6])=[#6]\c1c(Cl)c2c(Cl)cc(nc2n1-[#6]-1-[#6]-[#6]-[#6]-[#7]-[#6]-1)-[#6](-[#7])=O
Show InChI InChI=1S/C17H20Cl2N4O/c1-9(2)6-13-15(19)14-11(18)7-12(16(20)24)22-17(14)23(13)10-4-3-5-21-8-10/h6-7,10,21H,3-5,8H2,1-2H3,(H2,20,24)
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair