BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with Target = 'Sodium-dependent serotonin transporter' and Ligand = 'BDBM22166'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM22166 (3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	0.460	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Displacement of [3H]cyanoimipramine from SERT in rat cerebral cortex homogenate				Bioorg Med Chem Lett 16: 5222-5 (2006) Article DOI: 10.1016/j.bmcl.2006.07.013 BindingDB Entry DOI: 10.7270/Q2N29WMF
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM22166 (3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NIH Curated by PDSP K_i Database									Synapse 39: 32-41 (2001) Article DOI: 10.1002/1098-2396(20010101)39:1 BindingDB Entry DOI: 10.7270/Q2NV9GT3
NIH Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM22166 (3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM U316 Curated by PDSP K_i Database									J Pharmacol Exp Ther 282: 467-74 (1997) BindingDB Entry DOI: 10.7270/Q2X928VC
INSERM U316 Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM22166 (3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by PDSP K_i Database									J Pharmacol Exp Ther 289: 1229-36 (1999) BindingDB Entry DOI: 10.7270/Q2TX3CWQ
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22166 (3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aarhus University Curated by ChEMBL					Assay Description Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant SERT expressed in african gree...				Bioorg Med Chem 17: 4900-9 (2009) Article DOI: 10.1016/j.bmc.2009.06.007 BindingDB Entry DOI: 10.7270/Q24749Z2
Aarhus University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22166 (3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of Vienna Curated by ChEMBL					Assay Description Binding affinity to SERT (unknown origin)				Bioorg Med Chem 21: 7562-9 (2013) Article DOI: 10.1016/j.bmc.2013.10.046 BindingDB Entry DOI: 10.7270/Q27P92BD
Medical University of Vienna Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM22166 (3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	66.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by PDSP K_i Database									J Pharmacol Exp Ther 289: 1229-36 (1999) BindingDB Entry DOI: 10.7270/Q2TX3CWQ
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22166 (3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	2.82	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Displacement of [125I]beta-CIT from human SERT in human platelet membrane in presence of 5 uM ibogaine				J Biol Chem 282: 29441-7 (2007) Article DOI: 10.1074/jbc.M704456200 BindingDB Entry DOI: 10.7270/Q2125SG9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM22166 (3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	0.880	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Displacement of [125I]beta-CIT from human SERT in human platelet plasma membrane				J Biol Chem 282: 29441-7 (2007) Article DOI: 10.1074/jbc.M704456200 BindingDB Entry DOI: 10.7270/Q2125SG9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair