Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50005247 ((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by PDSP Ki Database | Mol Pharmacol 63: 1223-9 (2003) Article DOI: 10.1124/mol.63.6.1223 BindingDB Entry DOI: 10.7270/Q2FN14SJ | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50005247 ((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas at Austin Curated by PDSP Ki Database | J Pharmacol Exp Ther 311: 298-306 (2004) Article DOI: 10.1124/jpet.104.069260 BindingDB Entry DOI: 10.7270/Q2CJ8C21 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50005247 ((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 478 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Activity towards Serotonin transporter was determined by the ability to inhibit [3H]-5-HT uptake in rat synaptosomes | J Med Chem 41: 1001-5 (1998) Article DOI: 10.1021/jm9705925 BindingDB Entry DOI: 10.7270/Q23777VQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50005247 ((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 478 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College Curated by ChEMBL | Assay Description Inhibition of [3H]5-HT uptake at SERT in rat brain synaptosome | Eur J Med Chem 44: 4862-88 (2009) Article DOI: 10.1016/j.ejmech.2009.07.027 BindingDB Entry DOI: 10.7270/Q24J0F7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50005247 ((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 478 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College Curated by ChEMBL | Assay Description Binding affinity to human SERT | Bioorg Med Chem 18: 4009-31 (2010) Article DOI: 10.1016/j.bmc.2010.04.022 BindingDB Entry DOI: 10.7270/Q2ST7Q1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50005247 ((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College Curated by ChEMBL | Assay Description Inhibition of [3H]-serotonin reuptake at human SERT expressed in HEK293 cells after 15 to 20 mins by fluorescence neurotransmitter transporter assay | Bioorg Med Chem 19: 1328-48 (2011) Article DOI: 10.1016/j.bmc.2010.11.054 BindingDB Entry DOI: 10.7270/Q28C9WJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50005247 ((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 996 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College Curated by ChEMBL | Assay Description Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation counting | Eur J Med Chem 44: 4862-88 (2009) Article DOI: 10.1016/j.ejmech.2009.07.027 BindingDB Entry DOI: 10.7270/Q24J0F7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50005247 ((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Activity at SERT in rat synaptosomes assessed as release of [3H]HT after 5 mins by liquid scintillation counting method | J Med Chem 60: 2605-2628 (2017) Article DOI: 10.1021/acs.jmedchem.7b00085 BindingDB Entry DOI: 10.7270/Q2DJ5HWM | |||||||||||
More data for this Ligand-Target Pair |