Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Toll-like receptor 8' and Ligand = 'BDBM427673'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM427673 (1-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(CC(C)(C)O)CC1)-c1cn2ncnc2c(C)c1C Show InChI InChI=1S/C26H35N7O/c1-16(2)22-23(19-13-33-25(27-15-28-33)18(4)17(19)3)29-20-7-8-21(30-24(20)22)32-11-9-31(10-12-32)14-26(5,6)34/h7-8,13,15-16,29,34H,9-12,14H2,1-6H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM427673 (1-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(CC(C)(C)O)CC1)-c1cn2ncnc2c(C)c1C Show InChI InChI=1S/C26H35N7O/c1-16(2)22-23(19-13-33-25(27-15-28-33)18(4)17(19)3)29-20-7-8-21(30-24(20)22)32-11-9-31(10-12-32)14-26(5,6)34/h7-8,13,15-16,29,34H,9-12,14H2,1-6H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S46W4Z
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM427673 (1-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(CC(C)(C)O)CC1)-c1cn2ncnc2c(C)c1C Show InChI InChI=1S/C26H35N7O/c1-16(2)22-23(19-13-33-25(27-15-28-33)18(4)17(19)3)29-20-7-8-21(30-24(20)22)32-11-9-31(10-12-32)14-26(5,6)34/h7-8,13,15-16,29,34H,9-12,14H2,1-6H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10730877 (2020) BindingDB Entry DOI: 10.7270/Q2H41VH3
					More data for this Ligand-Target Pair