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Found 1 hit Enz. Inhib. hit(s) with Target = 'Transcription initiation factor TFIID subunit 1 [1381-1497]' and Ligand = 'BDBM346512'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transcription initiation factor TFIID subunit 1 [1381-1497]


(Homo sapiens (human))		BDBM346512
PNG
(US10202378, Example 116 | [2-(trifluoromethyl)phen...)
Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1C(F)(F)F)c(cn(C)c2=O)C#CC(C)(C)O
Show InChI InChI=1S/C23H21F3N2O4/c1-13-17(21(30)32-12-15-7-5-6-8-16(15)23(24,25)26)18-14(9-10-22(2,3)31)11-28(4)20(29)19(18)27-13/h5-8,11,27,31H,12H2,1-4H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 105n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...

US Patent US10202378 (2019)


BindingDB Entry DOI: 10.7270/Q22B9149
More data for this
Ligand-Target Pair