BindingDB PrimarySearch

Found 4 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 1' and Ligand = 'BDBM50142759'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50142759 ((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Sookmyung Women's University Curated by ChEMBL					Assay Description Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated intracellular 45Ca2+ influx by scintillat...				Bioorg Med Chem 18: 111-6 (2010) Article DOI: 10.1016/j.bmc.2009.11.014 BindingDB Entry DOI: 10.7270/Q2TQ61NH
Sookmyung Women's University Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50142759 ((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Sookmyung Women's University Curated by ChEMBL					Assay Description Antagonist activity at TRPV1 in neonatal rat DRG neurons assessed as inhibition of capsaicin-induced intracellular calcium after 10 mins in presence ...				Bioorg Med Chem Lett 28: 2080-2083 (2018) Article DOI: 10.1016/j.bmcl.2018.04.044 BindingDB Entry DOI: 10.7270/Q2NZ8B44
Sookmyung Women's University Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50142759 ((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Sookmyung Women's University Curated by ChEMBL					Assay Description Agonist activity at TRPV1 in neonatal rat DRG neurons assessed as increase in calcium influx after 10 mins in presence of 45Ca2+ by Beckman CP scinti...				Bioorg Med Chem Lett 28: 2080-2083 (2018) Article DOI: 10.1016/j.bmcl.2018.04.044 BindingDB Entry DOI: 10.7270/Q2NZ8B44
Sookmyung Women's University Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50142759 ((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Sookmyung Women's University Curated by ChEMBL					Assay Description Agonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as intracellular 45Ca2+ influx by scintillation counting				Bioorg Med Chem 18: 111-6 (2010) Article DOI: 10.1016/j.bmc.2009.11.014 BindingDB Entry DOI: 10.7270/Q2TQ61NH
Sookmyung Women's University Curated by ChEMBL					More data for this Ligand-Target Pair