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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tryptophan 2,3-dioxygenase' and Ligand = 'BDBM347022'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tryptophan 2,3-dioxygenase


(Homo sapiens (Human))		BDBM347022
PNG
(US10202388, Compound 23A-2 | US10202388, Compound ...)
Show SMILES O[C@H](CC1c2c(cccc2F)-c2cncn12)C12CC3CC(C1)[C@H](O)C(C3)C2 |r,wU:22.26,wD:1.0,TLB:21:16:25:22.20.19,23:22:25:16.17.26,23:22:16.21.26:25.18.19,1:16:22:25.18.19,THB:17:16:22:25.18.19,17:18:22:16.21.26,21:20:25:16.17.26,(.35,-1.49,;.35,.05,;-.98,.82,;-2.31,.05,;-3.72,.68,;-4.75,-.47,;-6.26,-.15,;-6.73,1.32,;-5.7,2.46,;-4.2,2.14,;-3.17,3.29,;-3.98,-1.8,;-4.14,-3.33,;-2.74,-3.96,;-1.71,-2.81,;-2.48,-1.48,;1.69,.82,;1.69,2.36,;3.01,3.13,;3.77,1.97,;3.79,-.43,;2.58,-1.1,;5.18,-1.08,;6.65,-.61,;4.35,.82,;4.35,2.36,;3.01,.05,)|
Show InChI InChI=1S/C22H25FN2O2/c23-16-3-1-2-15-18-10-24-11-25(18)17(20(15)16)6-19(26)22-7-12-4-13(8-22)21(27)14(5-12)9-22/h1-3,10-14,17,19,21,26-27H,4-9H2/t12?,13?,14?,17?,19-,21-,22?/m1/s1
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US Patent
n/an/a 300n/an/an/an/an/an/a



SHANGHAI DE NOVO PHARMATECH CO., LTD.

US Patent


Assay Description
The TDO2 enzymatic assay was performed by UV absorption using a recombinant TDO2 and L-Tryptophan substrate. The UV absorption signal at 321 nm is co...

US Patent US10202388 (2019)


BindingDB Entry DOI: 10.7270/Q2JD4ZXX
More data for this
Ligand-Target Pair