Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tubulin beta chain (Sus scrofa) | BDBM50030765 (NPI-2358 | Plinabulin) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Pharmacy and Life Sciences Curated by ChEMBL | Assay Description Inhibition of porcine tubulin polymerization by spectrophotometry | ACS Med Chem Lett 5: 1094-8 (2014) Article DOI: 10.1021/ml5001883 BindingDB Entry DOI: 10.7270/Q2R49SCP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50030765 (NPI-2358 | Plinabulin) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Pharmacy and Life Sciences Curated by ChEMBL | Assay Description Binding affinity to pig tubulin after 1 hr by fluorescence quenching analysis | Bioorg Med Chem 18: 3169-74 (2010) Article DOI: 10.1016/j.bmc.2010.03.037 BindingDB Entry DOI: 10.7270/Q2QR50Z5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50030765 (NPI-2358 | Plinabulin) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Pharmacy and Life Sciences Curated by ChEMBL | Assay Description Binding affinity to porcine tubulin after 1 hr by spectrofluorometric analysis | J Med Chem 55: 1056-71 (2012) Article DOI: 10.1021/jm2009088 BindingDB Entry DOI: 10.7270/Q20R9S8Q | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50030765 (NPI-2358 | Plinabulin) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Pharmacy and Life Sciences Curated by ChEMBL | Assay Description Binding affinity to porcine tubulin after 1 hr by spectrofluorometric analysis | Bioorg Med Chem 19: 595-602 (2011) Article DOI: 10.1016/j.bmc.2010.10.055 BindingDB Entry DOI: 10.7270/Q2WS8X2Q | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |