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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM143327'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM143327
PNG
(US8940893, 12)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(-c3ccc(Oc4ccccc4)cn3)c3c(N)ncnc23)C1
Show InChI InChI=1S/C26H23N7O2/c1-2-6-21(34)32-14-26(15-32)11-17(12-26)33-25-22(24(27)29-16-30-25)23(31-33)20-10-9-19(13-28-20)35-18-7-4-3-5-8-18/h3-5,7-10,13,16-17H,11-12,14-15H2,1H3,(H2,27,29,30)
PDB
MMDB

NCI pathway
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PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
An HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation of ...


US Patent US8940893 (2015)


BindingDB Entry DOI: 10.7270/Q2PV6J3P
More data for this
Ligand-Target Pair