Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM174406'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM174406 (US9688676, 8 (R)-2-(3-(4-amino-2-oxo-3-(4-phenoxyp...) Show SMILES Nc1nccc2n([C@@H]3CCCN(C3)C(=O)C(=CC3CCC3)C#N)c(=O)n(-c3ccc(Oc4ccccc4)cc3)c12 |r,w:16.17| Show InChI InChI=1S/C31H30N6O3/c32-19-22(18-21-6-4-7-21)30(38)35-17-5-8-24(20-35)36-27-15-16-34-29(33)28(27)37(31(36)39)23-11-13-26(14-12-23)40-25-9-2-1-3-10-25/h1-3,9-16,18,21,24H,4-8,17,20H2,(H2,33,34)/t24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	25
PRINCIPIA BIOPHARMA INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of BTK kinase activity of a compound of the pre...				US Patent US9688676 (2017) BindingDB Entry DOI: 10.7270/Q2XD0ZVX
					More data for this Ligand-Target Pair