Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM267491'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM267491 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) Show SMILES CCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H]3CC[C@H](O)CC3)n3ccnc(N)c23)c1 |r,wU:19.19,wD:22.23,(-.4,9.57,;1.08,9.97,;2.17,8.88,;3.66,9.28,;4.75,8.19,;4.35,6.7,;2.86,6.31,;2.46,4.82,;.98,4.42,;-.11,5.51,;.58,2.93,;1.67,1.84,;1.27,.36,;-.22,-.04,;-1.31,1.05,;-.91,2.53,;-.62,-1.53,;.29,-2.78,;-.62,-4.02,;-.22,-5.51,;1.27,-5.91,;1.67,-7.4,;.58,-8.48,;.98,-9.97,;-.91,-8.09,;-1.31,-6.6,;-2.08,-3.55,;-3.42,-4.32,;-4.75,-3.55,;-4.75,-2.01,;-3.42,-1.24,;-3.42,.3,;-2.08,-2.01,;1.77,7.4,)| Show InChI InChI=1S/C26H28N6O2/c1-2-16-11-12-28-21(15-16)30-26(34)19-5-3-17(4-6-19)22-23-24(27)29-13-14-32(23)25(31-22)18-7-9-20(33)10-8-18/h3-6,11-15,18,20,33H,2,7-10H2,1H3,(H2,27,29)(H,28,30,34)/t18-,20-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<10	n/a	n/a	7.2	25
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent					Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...				US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T
					More data for this Ligand-Target Pair