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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM267491 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Btk Enzyme Activity Assay A | ||
| pH | 7.2±n/a | ||
| Temperature | 298.15±n/a K | ||
| EC50 | <10.00±n/a nM | ||
| Comments | extracted | ||
| Citation |  De Man, AP; Sterrenburg, J; Raaijmakers, HC; Kaptein, A; Oubrie, AA; Rewinkel, JB; Jans, CG; Wijkmans, JC; Barf, TA; Cooper, AB; Kim, RM; Boga, SB; Zhu, HY; Gao, X; Yao, X; Anand, R; Wu, H; Liu, S; Yang, C; Alhassan, A; Wang, J; Yu, Y; Liu, J; Vaccaro, HM BTK Inhibitors US Patent US9718828 Publication Date 8/1/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
| ||
| BDBM267491 | |||
| n/a | |||
| Name | BDBM267491 | ||
| Synonyms: | 4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[1,5-a]pyrazin-1-yl)-N-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide | US9718828, Example, 19 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H28N6O2 | ||
| Mol. Mass. | 456.5395 | ||
| SMILES | CCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H]3CC[C@H](O)CC3)n3ccnc(N)c23)c1 |r,wU:19.19,wD:22.23,(-.4,9.57,;1.08,9.97,;2.17,8.88,;3.66,9.28,;4.75,8.19,;4.35,6.7,;2.86,6.31,;2.46,4.82,;.98,4.42,;-.11,5.51,;.58,2.93,;1.67,1.84,;1.27,.36,;-.22,-.04,;-1.31,1.05,;-.91,2.53,;-.62,-1.53,;.29,-2.78,;-.62,-4.02,;-.22,-5.51,;1.27,-5.91,;1.67,-7.4,;.58,-8.48,;.98,-9.97,;-.91,-8.09,;-1.31,-6.6,;-2.08,-3.55,;-3.42,-4.32,;-4.75,-3.55,;-4.75,-2.01,;-3.42,-1.24,;-3.42,.3,;-2.08,-2.01,;1.77,7.4,)| | ||
| Structure | 
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