Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase Fyn (Homo sapiens (Human)) | BDBM50357312 (IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 95.6 | n/a | n/a | n/a | n/a | n/a | n/a |
PHARMACYCLICS LLC US Patent | Assay Description IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in... | US Patent US9181263 (2015) BindingDB Entry DOI: 10.7270/Q2765D5Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Fyn (Homo sapiens (Human)) | BDBM50357312 (IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 95.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacyclics LLC US Patent | Assay Description IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition... | US Patent US9278100 (2016) BindingDB Entry DOI: 10.7270/Q20C4TMX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Fyn (Homo sapiens (Human)) | BDBM50357312 (IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human FYN using biotinyl-beta Abeta-Abeta AYQAEENTYDEYEN as substrate incubate for 60 mins by LANCE assay | Citation and Details Article DOI: 10.1016/j.ejmech.2017.12.079 BindingDB Entry DOI: 10.7270/Q2P272TR | |||||||||||
More data for this Ligand-Target Pair |