Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM182238'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182238 (US9145391, 10) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(C[C@H]2CC[C@@H](CC2)C(O)=O)nc1 |r,wU:23.24,wD:26.31,(2.67,7.34,;1.33,8.11,;,7.34,;-1.33,8.11,;-2.67,7.34,;-4,8.11,;-4,9.65,;-5.33,10.42,;-6.67,9.65,;-6.67,8.11,;-5.33,7.34,;-5.33,11.96,;-6.67,12.73,;-4,12.73,;-5.33,13.5,;-1.33,9.65,;,10.42,;1.33,9.65,;,11.96,;-1.33,12.73,;-1.33,14.27,;,15.04,;,16.58,;1.33,17.35,;1.33,18.89,;2.67,19.66,;4,18.89,;4,17.35,;2.67,16.58,;5.33,19.66,;6.67,18.89,;5.33,21.2,;1.33,14.27,;1.33,12.73,)| Show InChI InChI=1S/C25H25F3N4O2/c1-15-10-21(31-23(11-15)32-22-13-19(8-9-29-22)25(26,27)28)18-6-7-20(30-14-18)12-16-2-4-17(5-3-16)24(33)34/h6-11,13-14,16-17H,2-5,12H2,1H3,(H,33,34)(H,29,31,32)/t16-,17-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9145391 (2015) BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
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