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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM205291'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM205291
PNG
(US9249125, 44)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc4[nH]nc(OCCN5CCOCC5)c4c3)n2)c2ccccc12)C(C)C
Show InChI InChI=1S/C41H42N10O5/c1-26(2)35-25-37(51(49-35)28-9-11-29(53-3)12-10-28)45-41(52)44-33-14-15-36(31-7-5-4-6-30(31)33)56-38-16-17-42-40(46-38)43-27-8-13-34-32(24-27)39(48-47-34)55-23-20-50-18-21-54-22-19-50/h4-17,24-26H,18-23H2,1-3H3,(H,47,48)(H,42,43,46)(H2,44,45,52)
PDB
MMDB

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US Patent
n/an/a 2n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9249125 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72QG
More data for this
Ligand-Target Pair