Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM212258'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212258 (US9290490, Example 15) Show SMILES C[C@@](O)([C@H]1CC[C@@H](CC1)C(O)=O)c1ncc(s1)-c1cc(CO)cc(Nc2nccc(n2)C(F)(F)F)c1 |r,wU:1.1,6.9,wD:1.12,3.8,(-.42,-5.66,;.83,-4.75,;2.07,-3.85,;1.73,-6,;1.11,-7.4,;2.01,-8.65,;3.54,-8.49,;4.17,-7.08,;3.27,-5.84,;4.45,-9.73,;5.98,-9.57,;3.82,-11.14,;-.08,-3.5,;-1.62,-3.5,;-2.09,-2.04,;-.85,-1.13,;.4,-2.04,;-.85,.41,;.49,1.18,;.49,2.72,;1.82,3.49,;3.15,2.72,;-.85,3.49,;-2.18,2.72,;-3.51,3.49,;-3.51,5.03,;-2.18,5.8,;-2.18,7.34,;-3.51,8.11,;-4.85,7.34,;-4.85,5.8,;-6.18,8.11,;-7.51,8.88,;-5.41,9.44,;-6.95,6.77,;-2.18,1.18,)| Show InChI InChI=1S/C24H25F3N4O4S/c1-23(35,16-4-2-14(3-5-16)20(33)34)21-29-11-18(36-21)15-8-13(12-32)9-17(10-15)30-22-28-7-6-19(31-22)24(25,26)27/h6-11,14,16,32,35H,2-5,12H2,1H3,(H,33,34)(H,28,30,31)/t14-,16-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9290490 (2016) BindingDB Entry DOI: 10.7270/Q2Z0370B
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