BindingDB PrimarySearch

Found 20 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM212271'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) using XL665-labeled peptide as substrate in presence of ATP measured after 30 mins by TR-FRET assay				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	13.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...				Citation and Details BindingDB Entry DOI: 10.7270/Q2KD22RG
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	13.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee					Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...				Bioorg Med Chem 16: 8853-62 (2008) BindingDB Entry DOI: 10.7270/Q2K076M3
University of Wisconsin-Milwaukee					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	13.5	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...				US Patent US10342794 (2019) BindingDB Entry DOI: 10.7270/Q2R49T3H
Gilead Sciences Inc US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	13.5	n/a	n/a	n/a	n/a	7.0	n/a
Gilead Sciences, Inc. US Patent					Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...				US Patent US9290505 (2016) BindingDB Entry DOI: 10.7270/Q2TB15RT
Gilead Sciences, Inc. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	13.5	n/a	n/a	n/a	n/a	7.0	25
Gilead Sciences, Inc. US Patent					Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...				US Patent US9504684 (2016) BindingDB Entry DOI: 10.7270/Q2XS5TB7
Gilead Sciences, Inc. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	13.5	n/a	n/a	n/a	n/a	n/a	n/a
KRONOS BIO, INC. US Patent					Assay Description Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...				US Patent US10828299 (2020) BindingDB Entry DOI: 10.7270/Q2PK0K6D
KRONOS BIO, INC. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated BTK phosphorylation at Y223 residue				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated AKT phosphorylation at S473 residue				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	37	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated ERK phosphorylation at T202/Y204 residue				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	51	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated MEK phosphorylation at S217/S221 residue				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	112	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated B cells activation by measuring reduction in CD69 express...				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	164	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) in B cells assessed as reduction in alpha IgM-stimulated B cells activation by measuring reduction in CD86 express...				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK-mediated alpha CD3/alpha CD28-stimulated human T lymphocytes proliferation measured after 90 hrs by EdU incorporation assay				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) in macrophages assessed as reduction in immune complex-stimulated TNFalpha secretion				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) in macrophages assessed as reduction in immune complex-stimulated IL-1 beta secretion				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) in macrophages assessed as reduction in immune complex-stimulated IL-6 secretion				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	73	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-induced basophil activation by measuring decrease in CD63 surfac...				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212271 (6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piper...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	108	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Inhibition of SYK-mediated alpha IgM/alpha CD40-stimulated human B lymphocytes proliferation pretreated for 1 hr followed by stimulation with alpha I...				ACS Med Chem Lett 11: 506-513 (2020) Article DOI: 10.1021/acsmedchemlett.9b00621 BindingDB Entry DOI: 10.7270/Q2ZG6WR1
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)