Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM50431378'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50431378 (CHEMBL2347414) Show SMILES Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@]4(C)C[C@H](N)C4)c3n2)c2ccc(F)cc12 |r,wU:17.17,14.14,wD:14.13,(53.18,-18.88,;51.65,-18.73,;50.62,-19.88,;49.21,-19.26,;47.88,-20.04,;47.89,-21.59,;46.55,-22.36,;45.21,-21.59,;43.75,-22.07,;42.83,-20.82,;43.74,-19.57,;43.25,-18.11,;44.28,-16.96,;41.75,-17.79,;41.26,-16.33,;40.16,-17.41,;41.96,-14.96,;40.58,-14.26,;40.1,-12.8,;39.89,-15.64,;45.21,-20.04,;46.55,-19.27,;49.37,-17.72,;48.34,-16.59,;48.8,-15.14,;50.3,-14.8,;50.77,-13.34,;51.34,-15.94,;50.87,-17.4,)| Show InChI InChI=1S/C20H20FN7O/c1-20(6-11(22)7-20)26-19(29)13-8-23-18-17(13)25-14(9-24-18)16-12-4-3-10(21)5-15(12)28(2)27-16/h3-5,8-9,11H,6-7,22H2,1-2H3,(H,23,24)(H,26,29)/t11-,20-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant truncated SYK (360 to 365 amino acid residues) using N-terminally biotinylated EPEGDYEEVLE peptide as substrate asses...				J Med Chem 56: 1677-92 (2013) Article DOI: 10.1021/jm301720p BindingDB Entry DOI: 10.7270/Q22N53M0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50431378 (CHEMBL2347414) Show SMILES Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@]4(C)C[C@H](N)C4)c3n2)c2ccc(F)cc12 |r,wU:17.17,14.14,wD:14.13,(53.18,-18.88,;51.65,-18.73,;50.62,-19.88,;49.21,-19.26,;47.88,-20.04,;47.89,-21.59,;46.55,-22.36,;45.21,-21.59,;43.75,-22.07,;42.83,-20.82,;43.74,-19.57,;43.25,-18.11,;44.28,-16.96,;41.75,-17.79,;41.26,-16.33,;40.16,-17.41,;41.96,-14.96,;40.58,-14.26,;40.1,-12.8,;39.89,-15.64,;45.21,-20.04,;46.55,-19.27,;49.37,-17.72,;48.34,-16.59,;48.8,-15.14,;50.3,-14.8,;50.77,-13.34,;51.34,-15.94,;50.87,-17.4,)| Show InChI InChI=1S/C20H20FN7O/c1-20(6-11(22)7-20)26-19(29)13-8-23-18-17(13)25-14(9-24-18)16-12-4-3-10(21)5-15(12)28(2)27-16/h3-5,8-9,11H,6-7,22H2,1-2H3,(H,23,24)(H,26,29)/t11-,20-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	427	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in human whole blood				J Med Chem 56: 1677-92 (2013) Article DOI: 10.1021/jm301720p BindingDB Entry DOI: 10.7270/Q22N53M0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50431378 (CHEMBL2347414) Show SMILES Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@]4(C)C[C@H](N)C4)c3n2)c2ccc(F)cc12 |r,wU:17.17,14.14,wD:14.13,(53.18,-18.88,;51.65,-18.73,;50.62,-19.88,;49.21,-19.26,;47.88,-20.04,;47.89,-21.59,;46.55,-22.36,;45.21,-21.59,;43.75,-22.07,;42.83,-20.82,;43.74,-19.57,;43.25,-18.11,;44.28,-16.96,;41.75,-17.79,;41.26,-16.33,;40.16,-17.41,;41.96,-14.96,;40.58,-14.26,;40.1,-12.8,;39.89,-15.64,;45.21,-20.04,;46.55,-19.27,;49.37,-17.72,;48.34,-16.59,;48.8,-15.14,;50.3,-14.8,;50.77,-13.34,;51.34,-15.94,;50.87,-17.4,)| Show InChI InChI=1S/C20H20FN7O/c1-20(6-11(22)7-20)26-19(29)13-8-23-18-17(13)25-14(9-24-18)16-12-4-3-10(21)5-15(12)28(2)27-16/h3-5,8-9,11H,6-7,22H2,1-2H3,(H,23,24)(H,26,29)/t11-,20-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in human Ramos cells				J Med Chem 56: 1677-92 (2013) Article DOI: 10.1021/jm301720p BindingDB Entry DOI: 10.7270/Q22N53M0
					More data for this Ligand-Target Pair