Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM135818'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM135818 (US10085990, Example 92 | US10568888, Example 92 | ...) Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-34-20-8-4-7-18-21(20)26-14-19-22(18)28(16-9-11-27(12-10-16)35(2,32)33)24(31)29(23(19)30)17-6-3-5-15(25)13-17/h3-8,13-14,16H,9-12H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
High Point Pharmaceuticals, LLC US Patent					Assay Description A TR-FRET-based phosphodiesterase assay kit from "Molecular Devices" was used to test whether these compounds were indeed direct inhibitors of the PD...				US Patent US8853226 (2014) BindingDB Entry DOI: 10.7270/Q28C9TZS
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM135818 (US10085990, Example 92 | US10568888, Example 92 | ...) Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-34-20-8-4-7-18-21(20)26-14-19-22(18)28(16-9-11-27(12-10-16)35(2,32)33)24(31)29(23(19)30)17-6-3-5-15(25)13-17/h3-8,13-14,16H,9-12H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...				US Patent US10568888 (2020) BindingDB Entry DOI: 10.7270/Q2ST7S7B
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM135818 (US10085990, Example 92 | US10568888, Example 92 | ...) Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C24H23ClN4O5S/c1-34-20-8-4-7-18-21(20)26-14-19-22(18)28(16-9-11-27(12-10-16)35(2,32)33)24(31)29(23(19)30)17-6-3-5-15(25)13-17/h3-8,13-14,16H,9-12H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	25
vTv Therapeutics LLC US Patent					Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...				US Patent US10085990 (2018) BindingDB Entry DOI: 10.7270/Q2RV0QRM
					More data for this Ligand-Target Pair