Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM135822'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM135822 (US10085990, Example 121 | US10568888, Example 121 ...) Show SMILES CCS(=O)(=O)N1CCC(CC1)n1c2c3cccc(OC)c3ncc2c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C25H25ClN4O5S/c1-3-36(33,34)28-12-10-17(11-13-28)29-23-19-8-5-9-21(35-2)22(19)27-15-20(23)24(31)30(25(29)32)18-7-4-6-16(26)14-18/h4-9,14-15,17H,3,10-13H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
High Point Pharmaceuticals, LLC US Patent					Assay Description A TR-FRET-based phosphodiesterase assay kit from "Molecular Devices" was used to test whether these compounds were indeed direct inhibitors of the PD...				US Patent US8853226 (2014) BindingDB Entry DOI: 10.7270/Q28C9TZS
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM135822 (US10085990, Example 121 | US10568888, Example 121 ...) Show SMILES CCS(=O)(=O)N1CCC(CC1)n1c2c3cccc(OC)c3ncc2c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C25H25ClN4O5S/c1-3-36(33,34)28-12-10-17(11-13-28)29-23-19-8-5-9-21(35-2)22(19)27-15-20(23)24(31)30(25(29)32)18-7-4-6-16(26)14-18/h4-9,14-15,17H,3,10-13H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...				US Patent US10568888 (2020) BindingDB Entry DOI: 10.7270/Q2ST7S7B
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM135822 (US10085990, Example 121 | US10568888, Example 121 ...) Show SMILES CCS(=O)(=O)N1CCC(CC1)n1c2c3cccc(OC)c3ncc2c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C25H25ClN4O5S/c1-3-36(33,34)28-12-10-17(11-13-28)29-23-19-8-5-9-21(35-2)22(19)27-15-20(23)24(31)30(25(29)32)18-7-4-6-16(26)14-18/h4-9,14-15,17H,3,10-13H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	25
vTv Therapeutics LLC US Patent					Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...				US Patent US10085990 (2018) BindingDB Entry DOI: 10.7270/Q2RV0QRM
					More data for this Ligand-Target Pair