Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4D' and Ligand = 'BDBM135823'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM135823 (US10085990, Example 122 | US10568888, Example 122 ...) Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)CS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C25H25ClN4O7S2/c1-37-21-8-4-7-19-22(21)27-14-20-23(19)29(25(32)30(24(20)31)18-6-3-5-16(26)13-18)17-9-11-28(12-10-17)39(35,36)15-38(2,33)34/h3-8,13-14,17H,9-12,15H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
High Point Pharmaceuticals, LLC US Patent					Assay Description A TR-FRET-based phosphodiesterase assay kit from "Molecular Devices" was used to test whether these compounds were indeed direct inhibitors of the PD...				US Patent US8853226 (2014) BindingDB Entry DOI: 10.7270/Q28C9TZS
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM135823 (US10085990, Example 122 | US10568888, Example 122 ...) Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)CS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C25H25ClN4O7S2/c1-37-21-8-4-7-19-22(21)27-14-20-23(19)29(25(32)30(24(20)31)18-6-3-5-16(26)13-18)17-9-11-28(12-10-17)39(35,36)15-38(2,33)34/h3-8,13-14,17H,9-12,15H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...				US Patent US10568888 (2020) BindingDB Entry DOI: 10.7270/Q2ST7S7B
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM135823 (US10085990, Example 122 | US10568888, Example 122 ...) Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)CS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C25H25ClN4O7S2/c1-37-21-8-4-7-19-22(21)27-14-20-23(19)29(25(32)30(24(20)31)18-6-3-5-16(26)13-18)17-9-11-28(12-10-17)39(35,36)15-38(2,33)34/h3-8,13-14,17H,9-12,15H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description A TR-FRET-based phosphodiesterase assay kit from Molecular Devices was used to test whether these compounds were indeed direct inhibitors of the PDE4...				US Patent US9833457 (2017) BindingDB Entry DOI: 10.7270/Q26W9DB9
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM135823 (US10085990, Example 122 | US10568888, Example 122 ...) Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)CS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C25H25ClN4O7S2/c1-37-21-8-4-7-19-22(21)27-14-20-23(19)29(25(32)30(24(20)31)18-6-3-5-16(26)13-18)17-9-11-28(12-10-17)39(35,36)15-38(2,33)34/h3-8,13-14,17H,9-12,15H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	25
vTv Therapeutics LLC US Patent					Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...				US Patent US10085990 (2018) BindingDB Entry DOI: 10.7270/Q2RV0QRM
					More data for this Ligand-Target Pair