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Found 1 hit Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM50258904'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50258904
PNG
(CHEMBL4094525)
Show SMILES CCC(NC(=O)N1CC(=O)Nc2cccnc12)c1ccc(cc1)C1CC1
Show InChI InChI=1S/C20H22N4O2/c1-2-16(15-9-7-14(8-10-15)13-5-6-13)23-20(26)24-12-18(25)22-17-4-3-11-21-19(17)24/h3-4,7-11,13,16H,2,5-6,12H2,1H3,(H,22,25)(H,23,26)
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n/an/a 80n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay

J Med Chem 60: 7677-7702 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00807
BindingDB Entry DOI: 10.7270/Q2P271JR
More data for this
Ligand-Target Pair