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Found 1 hit Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM50258927'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50258927
PNG
(CHEMBL4085934)
Show SMILES COCC(NC(=O)N1CC(=O)Nc2cc(OC(C)C)cnc12)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5/c1-12(2)32-15-8-16-19(25-9-15)28(10-18(29)26-16)20(30)27-17(11-31-3)13-4-6-14(7-5-13)33-21(22,23)24/h4-9,12,17H,10-11H2,1-3H3,(H,26,29)(H,27,30)
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n/an/a 77n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay

J Med Chem 60: 7677-7702 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00807
BindingDB Entry DOI: 10.7270/Q2P271JR
More data for this
Ligand-Target Pair