Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM50444037'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50444037 (CHEMBL3092564 | US8680116, 1-15) Show SMILES O=c1[nH]c2ccc(cc2c(OCC2CCNCC2)c1-c1cccs1)C#Cc1cccnc1 Show InChI InChI=1S/C26H23N3O2S/c30-26-24(23-4-2-14-32-23)25(31-17-20-9-12-27-13-10-20)21-15-18(7-8-22(21)29-26)5-6-19-3-1-11-28-16-19/h1-4,7-8,11,14-16,20,27H,9-10,12-13,17H2,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...				US Patent US8680116 (2014) BindingDB Entry DOI: 10.7270/Q2N29VM1
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