BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 10 hits Enz. Inhib. hit(s) with Target = 'cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B' and Ligand = 'BDBM50000315'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 3.40E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M

J Med Chem 32: 342-50 (1989)


BindingDB Entry DOI: 10.7270/Q27083P1
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 4.70E+3n/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Inhibition of human blood platelet c-AMP phosphodiesterase

J Med Chem 35: 620-8 (1992)


BindingDB Entry DOI: 10.7270/Q2PZ57SK
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricle

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of low Km cyclic cAMP phosphodiesterase PDE III of guinea pig ventricle

J Med Chem 28: 537-45 (1985)


BindingDB Entry DOI: 10.7270/Q2N58MXT
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of guinea pig phosphodiesterase type III

J Med Chem 29: 261-7 (1986)


BindingDB Entry DOI: 10.7270/Q2B56MZQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against cAMP PDE III enzyme in guinea pig

J Med Chem 30: 1955-62 (1987)


BindingDB Entry DOI: 10.7270/Q27S7MS4
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of fraction III of guinea pig phosphodiesterase

J Med Chem 27: 1099-101 (1984)


BindingDB Entry DOI: 10.7270/Q26Q1W70
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Inhibition of Guinea Pig cAMP specific phosphodiesterase (PDE III); range 4 to 10

J Med Chem 30: 1724-8 (1987)


BindingDB Entry DOI: 10.7270/Q20R9RN7
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cardiac phosphodiesterase-3 isolated from canine heart.

J Med Chem 33: 380-6 (1990)


BindingDB Entry DOI: 10.7270/Q241708F
More data for this
Ligand-Target Pair