Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'chymase' and Ligand = 'BDBM255966'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
chymase (Mesocricetus auratus (Golden hamster))	BDBM255966 (US9481672, 144) Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc4n(C)c(=O)n(CC(F)(F)F)c4c3)c2=O)C(O)=O)cccc1C(F)(F)F Show InChI InChI=1S/C24H18F6N4O5/c1-12-13(4-3-5-16(12)24(28,29)30)9-33-19(35)15(20(36)37)10-32(22(33)39)14-6-7-17-18(8-14)34(11-23(25,26)27)21(38)31(17)2/h3-8,10H,9,11H2,1-2H3,(H,36,37)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...				US Patent US9481672 (2016) BindingDB Entry DOI: 10.7270/Q20P0XZ7
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