Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Type-1 angiotensin II receptor (RABBIT) | BDBM82258 (CAS_114798-26-4 | Losartan | NSC_3961) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a |
The M. S. University of Baroda Curated by ChEMBL | Assay Description Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings | Bioorg Med Chem 18: 8418-56 (2010) Article DOI: 10.1016/j.bmc.2010.10.043 BindingDB Entry DOI: 10.7270/Q2H70G3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM82258 (CAS_114798-26-4 | Losartan | NSC_3961) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a |
Beijing Institute of Technology Curated by ChEMBL | Assay Description Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 6... | Eur J Med Chem 49: 183-90 (2012) Article DOI: 10.1016/j.ejmech.2012.01.009 BindingDB Entry DOI: 10.7270/Q29K4BPW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM82258 (CAS_114798-26-4 | Losartan | NSC_3961) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins | J Med Chem 51: 2137-46 (2008) Article DOI: 10.1021/jm7011563 BindingDB Entry DOI: 10.7270/Q20P10X0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet glycoprotein VI (Homo sapiens (Human)) | BDBM82258 (CAS_114798-26-4 | Losartan | NSC_3961) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopy | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00262 BindingDB Entry DOI: 10.7270/Q2V128FM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM82258 (CAS_114798-26-4 | Losartan | NSC_3961) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | 1.58 | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro binding affinity against Angiotensin II receptor in rabbit aorta rings | Bioorg Med Chem Lett 4: 87-92 (1994) Article DOI: 10.1016/S0960-894X(01)81127-6 BindingDB Entry DOI: 10.7270/Q2BC40QF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM82258 (CAS_114798-26-4 | Losartan | NSC_3961) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a |
School of Chemical Engineering& the Environment Curated by ChEMBL | Assay Description Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post ... | Bioorg Med Chem 20: 4208-16 (2012) Article DOI: 10.1016/j.bmc.2012.05.056 BindingDB Entry DOI: 10.7270/Q2GT5P7J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet glycoprotein VI (Homo sapiens (Human)) | BDBM82258 (CAS_114798-26-4 | Losartan | NSC_3961) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a | n/a |
Japan Biological Informatics Consortium (JBIC) Curated by ChEMBL | Assay Description Binding affinity to human N-terminal Ig-like domain D1D2 GPVI expressed in Escherichia coli DH5alpha by NMR spectroscopy | J Med Chem 53: 2087-93 (2010) Article DOI: 10.1021/jm901534d BindingDB Entry DOI: 10.7270/Q21C20PF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM82258 (CAS_114798-26-4 | Losartan | NSC_3961) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | 3.72 | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings | Bioorg Med Chem Lett 4: 173-176 (1994) Article DOI: 10.1016/S0960-894X(01)81142-2 BindingDB Entry DOI: 10.7270/Q2G44RFS | |||||||||||
More data for this Ligand-Target Pair |