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Compile Data Set for Download or QSAR

Found 48 hits Enz. Inhib. hit(s) with Target = 'Platelet glycoprotein VI'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50552053
PNG
(Glaucocalyxin A)
Show SMILES [H][C@@]12CC[C@]3([H])[C@]([C@@H]1O)([C@H](O)C[C@]1([H])C(C)(C)C(=O)CC[C@@]31C)C(=O)C2=C |r,THB:26:25:7:2.3.4,24:23:7:2.3.4|
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TBA

Assay Description
Antagonist activity at GP6 in human platelet assessed as reduction in CRP-induced platelet-aggregation preincubated for 10 mins followed by collagen ...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50552053
PNG
(Glaucocalyxin A)
Show SMILES [H][C@@]12CC[C@]3([H])[C@]([C@@H]1O)([C@H](O)C[C@]1([H])C(C)(C)C(=O)CC[C@@]31C)C(=O)C2=C |r,THB:26:25:7:2.3.4,24:23:7:2.3.4|
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TBA

Assay Description
Antagonist activity at GP6 in human platelet assessed as reduction in collagen-induced platelet-aggregation preincubated for 10 mins followed by coll...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50396073
PNG
(CHEMBL1235110)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1 |r|
Show InChI InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8-3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/t14-,15+/m0/s1
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n/an/a 31n/an/an/an/an/an/a


TBA

Assay Description
Modulation of GP6 in human platelets assessed as reduction in convulxin-induced platelet aggregation

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50396073
PNG
(CHEMBL1235110)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1 |r|
Show InChI InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8-3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/t14-,15+/m0/s1
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n/an/a 48n/an/an/an/an/an/a


TBA

Assay Description
Modulation of GP6 in human platelets assessed as reduction in convulxin-induced P-selectin expression preincubated for 20 mins followed by convulxin ...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50357312
PNG
(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m1/s1
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n/an/a 120n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of GP6 in human whole blood assessed as protein-mediated platelet aggregation preincubated for 15 mins followed by collagen stimulation an...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM250082
PNG
(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Show SMILES NC(=O)c1c2NCC[C@@H](C3CCN(CC3)C(=O)C=C)n2nc1-c1ccc(Oc2ccccc2)cc1 |r|
Show InChI InChI=1S/C27H29N5O3/c1-2-23(33)31-16-13-18(14-17-31)22-12-15-29-27-24(26(28)34)25(30-32(22)27)19-8-10-21(11-9-19)35-20-6-4-3-5-7-20/h2-11,18,22,29H,1,12-17H2,(H2,28,34)/t22-/m0/s1
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TBA

Assay Description
Inhibition of GP6 in human whole blood assessed as protein-mediated platelet aggregation preincubated for 15 mins followed by collagen stimulation an...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50396073
PNG
(CHEMBL1235110)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1 |r|
Show InChI InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8-3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/t14-,15+/m0/s1
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TBA

Assay Description
Modulation of GP6 in human platelets reduction in collagen-induced platelet aggregation preincubated for 20 mins followed by collagen stimulation

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM194087
PNG
(US20230364079, Example Tirabrutinib | US9199997, 9...)
Show SMILES CC#CC(=O)N1CC[C@H](C1)n1c2ncnc(N)c2n(-c2ccc(Oc3ccccc3)cc2)c1=O |r|
Show InChI InChI=1S/C25H22N6O3/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28)/t18-/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of GP6 in human whole blood assessed as protein-mediated platelet aggregation preincubated for 15 mins followed by collagen stimulation an...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50175583
PNG
(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Show SMILES [H][C@]1(CCCN1C(=O)C#CC)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 |r|
Show InChI InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1
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n/an/a 1.21E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of GP6 in human whole blood assessed as protein-mediated platelet aggregation preincubated for 15 mins followed by collagen stimulation an...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 4.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at GP6 in human platelet assessed as reduction in CRP-induced platelet-aggregation preincubated for 60 secs followed by collagen ...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 4.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at GP6 in human platelet assessed as reduction in collagen-induced platelet-aggregation preincubated for 60 secs followed by coll...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211284
PNG
(CHEMBL3959435)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2[nH]c3ccccc3c2CC1C(N)=O
Show InChI InChI=1S/C19H19N3O4S/c1-26-12-6-8-13(9-7-12)27(24,25)22-11-17-15(10-18(22)19(20)23)14-4-2-3-5-16(14)21-17/h2-9,18,21H,10-11H2,1H3,(H2,20,23)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CVX-induced platelet aggregation preincubated for 5 mins ...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM291522
PNG
(1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)...)
Show SMILES Nc1ncnc(NCC2CCN(CC2)C(=O)C=C)c1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H27N5O2/c1-2-22(31)30-14-12-18(13-15-30)16-27-25-23(24(26)28-17-29-25)19-8-10-21(11-9-19)32-20-6-4-3-5-7-20/h2-11,17-18H,1,12-16H2,(H3,26,27,28,29)
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n/an/a 5.84E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of GP6 in human whole blood assessed as protein-mediated platelet aggregation preincubated for 15 mins followed by collagen stimulation an...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211284
PNG
(CHEMBL3959435)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2[nH]c3ccccc3c2CC1C(N)=O
Show InChI InChI=1S/C19H19N3O4S/c1-26-12-6-8-13(9-7-12)27(24,25)22-11-17-15(10-18(22)19(20)23)14-4-2-3-5-16(14)21-17/h2-9,18,21H,10-11H2,1H3,(H2,20,23)
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n/an/a 6.70E+3n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation preincubated for 5 ...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211282
PNG
(CHEMBL308493)
Show SMILES CCCCc1nc(Cl)c(C=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C22H21ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,14H,2-3,8,13H2,1H3,(H,25,26,27,28)
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n/an/a 7.60E+3n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CRP-XL-induced platelet aggregation preincubated for 5 mi...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211280
PNG
(S007-1558 (S))
Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2[nH]c3ccccc3c2C[C@H]1C(N)=O |r|
Show InChI InChI=1S/C19H19N3O4S/c1-26-12-6-8-13(9-7-12)27(24,25)22-11-17-15(10-18(22)19(20)23)14-4-2-3-5-16(14)21-17/h2-9,18,21H,10-11H2,1H3,(H2,20,23)/t18-/m0/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CVX-induced platelet aggregation preincubated for 5 mins ...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 1.04E+4n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation preincubated for 5 ...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CVX-induced platelet aggregation preincubated for 5 mins ...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211282
PNG
(CHEMBL308493)
Show SMILES CCCCc1nc(Cl)c(C=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C22H21ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,14H,2-3,8,13H2,1H3,(H,25,26,27,28)
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n/an/a 1.61E+4n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation preincubated for 5 ...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211280
PNG
(S007-1558 (S))
Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2[nH]c3ccccc3c2C[C@H]1C(N)=O |r|
Show InChI InChI=1S/C19H19N3O4S/c1-26-12-6-8-13(9-7-12)27(24,25)22-11-17-15(10-18(22)19(20)23)14-4-2-3-5-16(14)21-17/h2-9,18,21H,10-11H2,1H3,(H2,20,23)/t18-/m0/s1
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n/an/a 2.53E+4n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation preincubated for 5 ...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50016900
PNG
((E)-N-[2-(3-Dimethylamino-propylsulfanyl)-phenyl]-...)
Show SMILES CN(C)CCCSc1ccccc1NC(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C20H24N2OS/c1-22(2)15-8-16-24-19-12-7-6-11-18(19)21-20(23)14-13-17-9-4-3-5-10-17/h3-7,9-14H,8,15-16H2,1-2H3,(H,21,23)/b14-13+
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n/an/a 3.50E+4n/an/an/an/an/an/a


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Assay Description
Antagonist activity at GP6 in human platelet assessed as reduction in CRP-induced platelet-aggregation preincubated for 60 secs followed by collagen ...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50016900
PNG
((E)-N-[2-(3-Dimethylamino-propylsulfanyl)-phenyl]-...)
Show SMILES CN(C)CCCSc1ccccc1NC(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C20H24N2OS/c1-22(2)15-8-16-24-19-12-7-6-11-18(19)21-20(23)14-13-17-9-4-3-5-10-17/h3-7,9-14H,8,15-16H2,1-2H3,(H,21,23)/b14-13+
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n/an/a 3.50E+4n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CRP-induced platelet aggregation preincubated for 60 sec ...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50016900
PNG
((E)-N-[2-(3-Dimethylamino-propylsulfanyl)-phenyl]-...)
Show SMILES CN(C)CCCSc1ccccc1NC(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C20H24N2OS/c1-22(2)15-8-16-24-19-12-7-6-11-18(19)21-20(23)14-13-17-9-4-3-5-10-17/h3-7,9-14H,8,15-16H2,1-2H3,(H,21,23)/b14-13+
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n/an/a 4.00E+4n/an/an/an/an/an/a


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Assay Description
Antagonist activity at GP6 in human platelet assessed as reduction in collagen-induced platelet-aggregation preincubated for 60 secs followed by coll...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50016900
PNG
((E)-N-[2-(3-Dimethylamino-propylsulfanyl)-phenyl]-...)
Show SMILES CN(C)CCCSc1ccccc1NC(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C20H24N2OS/c1-22(2)15-8-16-24-19-12-7-6-11-18(19)21-20(23)14-13-17-9-4-3-5-10-17/h3-7,9-14H,8,15-16H2,1-2H3,(H,21,23)/b14-13+
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n/an/a 4.00E+4n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation preincubated for 60...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211282
PNG
(CHEMBL308493)
Show SMILES CCCCc1nc(Cl)c(C=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C22H21ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,14H,2-3,8,13H2,1H3,(H,25,26,27,28)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CVX-induced platelet aggregation preincubated for 5 mins ...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211284
PNG
(CHEMBL3959435)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2[nH]c3ccccc3c2CC1C(N)=O
Show InChI InChI=1S/C19H19N3O4S/c1-26-12-6-8-13(9-7-12)27(24,25)22-11-17-15(10-18(22)19(20)23)14-4-2-3-5-16(14)21-17/h2-9,18,21H,10-11H2,1H3,(H2,20,23)
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n/an/a 5.35E+4n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CRP-XL-induced platelet aggregation preincubated for 5 mi...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211283
PNG
(CHEMBL2263356)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2[nH]c3ccccc3c2C[C@@H]1C(N)=O |r|
Show InChI InChI=1S/C19H19N3O4S/c1-26-12-6-8-13(9-7-12)27(24,25)22-11-17-15(10-18(22)19(20)23)14-4-2-3-5-16(14)21-17/h2-9,18,21H,10-11H2,1H3,(H2,20,23)/t18-/m1/s1
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n/an/a 8.68E+4n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CVX-induced platelet aggregation preincubated for 5 mins ...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211283
PNG
(CHEMBL2263356)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2[nH]c3ccccc3c2C[C@@H]1C(N)=O |r|
Show InChI InChI=1S/C19H19N3O4S/c1-26-12-6-8-13(9-7-12)27(24,25)22-11-17-15(10-18(22)19(20)23)14-4-2-3-5-16(14)21-17/h2-9,18,21H,10-11H2,1H3,(H2,20,23)/t18-/m1/s1
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n/an/a 1.26E+5n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation preincubated for 5 ...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 1.58E+5n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CRP-XL-induced platelet aggregation preincubated for 5 mi...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211280
PNG
(S007-1558 (S))
Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2[nH]c3ccccc3c2C[C@H]1C(N)=O |r|
Show InChI InChI=1S/C19H19N3O4S/c1-26-12-6-8-13(9-7-12)27(24,25)22-11-17-15(10-18(22)19(20)23)14-4-2-3-5-16(14)21-17/h2-9,18,21H,10-11H2,1H3,(H2,20,23)/t18-/m0/s1
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n/an/a 1.81E+5n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CRP-XL-induced platelet aggregation preincubated for 5 mi...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211283
PNG
(CHEMBL2263356)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2[nH]c3ccccc3c2C[C@@H]1C(N)=O |r|
Show InChI InChI=1S/C19H19N3O4S/c1-26-12-6-8-13(9-7-12)27(24,25)22-11-17-15(10-18(22)19(20)23)14-4-2-3-5-16(14)21-17/h2-9,18,21H,10-11H2,1H3,(H2,20,23)/t18-/m1/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CRP-XL-induced platelet aggregation preincubated for 5 mi...

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/an/a 1.70E+5n/an/an/an/an/a


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Assay Description
Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopy

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50049186
PNG
((S)-3-Methyl-2-{pentanoyl-[2'-(1H-tetrazol-5-yl)-b...)
Show SMILES CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
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n/an/an/a 1.00E+5n/an/an/an/an/a


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Assay Description
Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopy

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50241364
PNG
(4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-te...)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(C)(C)O
Show InChI InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)
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n/an/an/a 3.00E+5n/an/an/an/an/a


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Assay Description
Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopy

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50552059
PNG
(CHEMBL1532826)
Show SMILES Cc1ccccc1-c1nn[nH]n1
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n/an/an/a 1.10E+6n/an/an/an/an/a


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Assay Description
Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopy

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50552058
PNG
(CHEMBL4745006)
Show SMILES c1ccc(cc1)-c1ccccc1-c1nn[nH]n1
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n/an/an/a 3.60E+5n/an/an/an/an/a


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Assay Description
Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopy

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50533338
PNG
(CHEMBL3092388)
Show SMILES OC(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C13H10O2/c14-13(15)12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9H,(H,14,15)
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n/an/an/a 1.50E+6n/an/an/an/an/a


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Assay Description
Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopy

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50552057
PNG
(CHEMBL4752710)
Show SMILES c1ccc(cc1)-c1cccc(c1)-c1nn[nH]n1
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n/an/an/a 8.00E+4n/an/an/an/an/a


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Assay Description
Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopy

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50552056
PNG
(CHEMBL4797073)
Show SMILES C(Cc1ccccc1)Oc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
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n/an/an/a 5.20E+4n/an/an/an/an/a


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Assay Description
Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopy

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50552055
PNG
(CHEMBL4751401)
Show SMILES C(CCc1ccccc1)COc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
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n/an/an/a 8.50E+5n/an/an/an/an/a


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Assay Description
Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopy

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50552054
PNG
(CHEMBL4761944)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(O)=O |r|
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n/an/an/a 5.70E+4n/an/an/an/an/a


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Assay Description
Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopy

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM24183
PNG
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Show SMILES NCCCC(O)=O
Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
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n/an/an/a 41n/an/an/an/an/a


TBA

Assay Description
Binding affinity to human platelet lysate GP6 at 0.1 uM by surface plasmon resonance analysis

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50157304
PNG
(3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol | 3',5-...)
Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O
Show InChI InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
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n/an/an/a 2.89E+5n/an/an/an/an/a


TBA

Assay Description
Binding affinity to human platelet lysate GP6 at 100 uM by surface plasmon resonance analysis

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50157304
PNG
(3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol | 3',5-...)
Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O
Show InChI InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
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n/an/an/a 2.89E+5n/an/an/an/an/a


TBA

Assay Description
Binding affinity to human platelet lysate GP6 at 10 uM by surface plasmon resonance analysis

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00262
BindingDB Entry DOI: 10.7270/Q2V128FM
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/an/a 1.70E+5n/an/an/an/an/a



Japan Biological Informatics Consortium (JBIC)

Curated by ChEMBL


Assay Description
Binding affinity to human N-terminal Ig-like domain D1D2 GPVI expressed in Escherichia coli DH5alpha by NMR spectroscopy

J Med Chem 53: 2087-93 (2010)


Article DOI: 10.1021/jm901534d
BindingDB Entry DOI: 10.7270/Q21C20PF
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211287
PNG
(CHEMBL3957185)
Show SMILES C(Cc1ccccc1)Oc1ccc(cc1)-c1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C21H18N4O/c1-2-5-16(6-3-1)13-14-26-20-11-9-17(10-12-20)18-7-4-8-19(15-18)21-22-24-25-23-21/h1-12,15H,13-14H2,(H,22,23,24,25)
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n/an/an/a 5.20E+4n/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Binding affinity to GP6 receptor (unknown origin) by NMR method

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211285
PNG
(CHEMBL3948507)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(O)=O |r|
Show InChI InChI=1S/C43H52N8O13/c1-22(46-38(58)32(18-26-20-45-29-11-7-6-10-28(26)29)49-41(61)33(19-35(55)56)50-42(62)36(44)23(2)53)37(57)47-30(17-25-12-14-27(54)15-13-25)39(59)48-31(16-24-8-4-3-5-9-24)40(60)51-34(21-52)43(63)64/h3-15,20,22-23,30-34,36,45,52-54H,16-19,21,44H2,1-2H3,(H,46,58)(H,47,57)(H,48,59)(H,49,61)(H,50,62)(H,51,60)(H,55,56)(H,63,64)/t22-,23+,30-,31-,32-,33-,34-,36-/m0/s1
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n/an/an/a 5.70E+4n/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Binding affinity to GP6 receptor (unknown origin) by NMR method

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair
Platelet glycoprotein VI


(Homo sapiens (Human))		BDBM50211281
PNG
(CHEMBL3894250)
Show SMILES C(CCc1ccccc1)COc1ccc(cc1)-c1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C23H22N4O/c1-2-7-18(8-3-1)9-4-5-16-28-22-14-12-19(13-15-22)20-10-6-11-21(17-20)23-24-26-27-25-23/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,24,25,26,27)
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n/an/an/a 8.50E+5n/an/an/an/an/a



Academy of Scientific and Innovative Research

Curated by ChEMBL


Assay Description
Binding affinity to GP6 receptor (unknown origin) by NMR method

J Med Chem 60: 322-337 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01360
BindingDB Entry DOI: 10.7270/Q24T6MJ1
More data for this
Ligand-Target Pair