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Compile Data Set for Download or QSAR

Found 21 hits of ic50 for UniProtKB: P28839   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytosol aminopeptidase [33-68,L62W]


(Sus scrofa (Pig))
BDBM50457473
PNG
(CHEMBL4209822)
Show SMILES CC(C)C[C@@H]([C@H](O)C(=O)NO)C(=O)N[C@H](C(O)=O)c1ccccc1 |r|
Show InChI InChI=1S/C16H22N2O6/c1-9(2)8-11(13(19)15(21)18-24)14(20)17-12(16(22)23)10-6-4-3-5-7-10/h3-7,9,11-13,19,24H,8H2,1-2H3,(H,17,20)(H,18,21)(H,22,23)/t11-,12-,13-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase using LGG as substrate after 90 mins


J Med Chem 61: 6468-6490 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00782
BindingDB Entry DOI: 10.7270/Q28S4SHS
More data for this
Ligand-Target Pair
Cytosol aminopeptidase [33-68,L62W]


(Sus scrofa (Pig))
BDBM50457466
PNG
(CHEMBL4206158)
Show SMILES CC(C)C[C@@H]([C@H](O)C(=O)NO)C(=O)N[C@H](C(=O)OC1CCCC1)c1ccccc1 |r|
Show InChI InChI=1S/C21H30N2O6/c1-13(2)12-16(18(24)20(26)23-28)19(25)22-17(14-8-4-3-5-9-14)21(27)29-15-10-6-7-11-15/h3-5,8-9,13,15-18,24,28H,6-7,10-12H2,1-2H3,(H,22,25)(H,23,26)/t16-,17-,18-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase using LGG as substrate after 90 mins


J Med Chem 61: 6468-6490 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00782
BindingDB Entry DOI: 10.7270/Q28S4SHS
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 5.20E+3n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 1.12E+4n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 10 hrs measured every 6 mins by fluor...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534075
PNG
(CHEMBL4483393)
Show SMILES CCOC(=O)C1(Cc2cc(OCc3ccccc3)cc(OCc3ccccc3)c2C=N1)C(=O)OCC |c:32|
Show InChI InChI=1S/C29H29NO6/c1-3-33-27(31)29(28(32)34-4-2)17-23-15-24(35-19-21-11-7-5-8-12-21)16-26(25(23)18-30-29)36-20-22-13-9-6-10-14-22/h5-16,18H,3-4,17,19-20H2,1-2H3
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n/an/a 1.65E+4n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534075
PNG
(CHEMBL4483393)
Show SMILES CCOC(=O)C1(Cc2cc(OCc3ccccc3)cc(OCc3ccccc3)c2C=N1)C(=O)OCC |c:32|
Show InChI InChI=1S/C29H29NO6/c1-3-33-27(31)29(28(32)34-4-2)17-23-15-24(35-19-21-11-7-5-8-12-21)16-26(25(23)18-30-29)36-20-22-13-9-6-10-14-22/h5-16,18H,3-4,17,19-20H2,1-2H3
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n/an/a 3.36E+4n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 10 hrs measured every 6 mins by fluor...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase [33-68,L62W]


(Sus scrofa (Pig))
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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n/an/a 3.43E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig kidney cytosolic Leucyl aminopeptidase


J Nat Prod 58: 823-829 (1995)


Article DOI: 10.1021/np50120a001
BindingDB Entry DOI: 10.7270/Q2K937J6
More data for this
Ligand-Target Pair
Cytosol aminopeptidase [33-68,L62W]


(Sus scrofa (Pig))
BDBM50157555
PNG
(2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 3',4'-d...)
Show SMILES Oc1ccc(cc1O)-c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C15H10O4/c16-11-6-5-9(7-13(11)18)15-8-12(17)10-3-1-2-4-14(10)19-15/h1-8,16,18H
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n/an/a 3.51E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig kidney cytosolic Leucyl aminopeptidase


J Nat Prod 58: 823-829 (1995)


Article DOI: 10.1021/np50120a001
BindingDB Entry DOI: 10.7270/Q2K937J6
More data for this
Ligand-Target Pair
Cytosol aminopeptidase [33-68,L62W]


(Sus scrofa (Pig))
BDBM7459
PNG
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
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n/an/a 4.96E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig kidney cytosolic Leucyl aminopeptidase


J Nat Prod 58: 823-829 (1995)


Article DOI: 10.1021/np50120a001
BindingDB Entry DOI: 10.7270/Q2K937J6
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534077
PNG
(CHEMBL4464704)
Show SMILES OC(=O)C1Cc2cc(O)c(O)c(I)c2C=N1 |c:15|
Show InChI InChI=1S/C10H8INO4/c11-8-5-3-12-6(10(15)16)1-4(5)2-7(13)9(8)14/h2-3,6,13-14H,1H2,(H,15,16)
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n/an/a 6.36E+4n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534070
PNG
(CHEMBL4454667)
Show SMILES OC(=O)C1Cc2cc(O)c(O)c(Br)c2C=N1 |c:15|
Show InChI InChI=1S/C10H8BrNO4/c11-8-5-3-12-6(10(15)16)1-4(5)2-7(13)9(8)14/h2-3,6,13-14H,1H2,(H,15,16)
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n/an/a 6.83E+4n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534074
PNG
(CHEMBL4468968)
Show SMILES OC(=O)C1Cc2cc(O)c(I)cc2C=N1 |c:14|
Show InChI InChI=1S/C10H8INO3/c11-7-1-6-4-12-8(10(14)15)2-5(6)3-9(7)13/h1,3-4,8,13H,2H2,(H,14,15)
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n/an/a 6.93E+4n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534069
PNG
(CHEMBL4473220)
Show SMILES OC(=O)C1Cc2cc(O)c(Br)c(O)c2C=N1 |c:15|
Show InChI InChI=1S/C10H8BrNO4/c11-8-7(13)2-4-1-6(10(15)16)12-3-5(4)9(8)14/h2-3,6,13-14H,1H2,(H,15,16)
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n/an/a 7.68E+4n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534072
PNG
(CHEMBL4455383)
Show SMILES OC(=O)C1Cc2cc(O)c(O)cc2C=N1 |c:14|
Show InChI InChI=1S/C10H9NO4/c12-8-2-5-1-7(10(14)15)11-4-6(5)3-9(8)13/h2-4,7,12-13H,1H2,(H,14,15)
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n/an/a 1.11E+5n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534078
PNG
(CHEMBL4557950)
Show SMILES OC(=O)C1(O)Cc2cc(O)c(O)cc2C=N1 |c:15|
Show InChI InChI=1S/C10H9NO5/c12-7-1-5-3-10(16,9(14)15)11-4-6(5)2-8(7)13/h1-2,4,12-13,16H,3H2,(H,14,15)
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n/an/a 1.38E+5n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534081
PNG
(CHEMBL4460083)
Show SMILES OC(=O)C1CCc2cc(O)c(O)cc2C=N1 |c:15|
Show InChI InChI=1S/C11H11NO4/c13-9-3-6-1-2-8(11(15)16)12-5-7(6)4-10(9)14/h3-5,8,13-14H,1-2H2,(H,15,16)
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n/an/a 1.63E+5n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534071
PNG
(CHEMBL4563759)
Show SMILES OC(=O)C1Cc2cc(O)cc(O)c2C=N1 |c:14|
Show InChI InChI=1S/C10H9NO4/c12-6-1-5-2-8(10(14)15)11-4-7(5)9(13)3-6/h1,3-4,8,12-13H,2H2,(H,14,15)
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n/an/a 3.79E+5n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534080
PNG
(CHEMBL4576374)
Show SMILES OC(=O)C1Cc2c(O)c(O)cc(Br)c2C=N1 |c:15|
Show InChI InChI=1S/C10H8BrNO4/c11-6-2-8(13)9(14)4-1-7(10(15)16)12-3-5(4)6/h2-3,7,13-14H,1H2,(H,15,16)
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n/an/a 4.09E+5n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534073
PNG
(CHEMBL4537106)
Show SMILES OC(=O)C1Cc2cc(O)c(O)c(O)c2C=N1 |c:15|
Show InChI InChI=1S/C10H9NO5/c12-7-2-4-1-6(10(15)16)11-3-5(4)8(13)9(7)14/h2-3,6,12-14H,1H2,(H,15,16)
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n/an/a 7.81E+5n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534076
PNG
(CHEMBL4435767)
Show SMILES COc1cc2CCC(N=Cc2cc1OC)(C(=O)OCc1ccccc1)C(=O)OCc1ccccc1 |c:8|
Show InChI InChI=1S/C28H27NO6/c1-32-24-15-22-13-14-28(29-17-23(22)16-25(24)33-2,26(30)34-18-20-9-5-3-6-10-20)27(31)35-19-21-11-7-4-8-12-21/h3-12,15-17H,13-14,18-19H2,1-2H3
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n/an/a 1.05E+6n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Sus scrofa)
BDBM50534079
PNG
(CHEMBL4456116)
Show SMILES C[C@]1(Cc2cc(O)c(O)cc2C2C(Cl)C(=O)N12)C(O)=O |r|
Show InChI InChI=1S/C13H12ClNO5/c1-13(12(19)20)4-5-2-7(16)8(17)3-6(5)10-9(14)11(18)15(10)13/h2-3,9-10,16-17H,4H2,1H3,(H,19,20)/t9?,10?,13-/m0/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
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PC cid
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UniChem
Article
PubMed
n/an/a 1.11E+6n/an/an/an/an/an/a



National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...


Bioorg Med Chem 24: 5302-5314 (2016)


Article DOI: 10.1016/j.bmc.2016.08.054
BindingDB Entry DOI: 10.7270/Q2NK3JHV
More data for this
Ligand-Target Pair