Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM250505 (US9464103, (6aR,7S,10aS)-10a-(4-chlorobenzenesulfo...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM250501 (US9464103, (6'S,6aR,7s,10aS)-10a-(4-chlorobenz...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM50129277 (CHEMBL3629739 | US9464103, (6aR,10aS)-10a-(4-chlor...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 10.1 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM50129269 (CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 13.9 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM50129272 (CHEMBL3629743 | US9464103, (6aR,7S,10aS)-10a-(4-ch...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 23.3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM50129278 (CHEMBL3629742 | US9464103, (6aR,10aS)-10a-(4-chlor...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 26.4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM50129271 (CHEMBL3629741 | US9464103, (6aR,10aS)-10a-(4-chlor...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 57.7 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM50129276 (CHEMBL3629737 | US9464103, (6aR,10aS)-10a-(4-chlor...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 66.6 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM250504 (US9464103, (6'S,6aR,7s,10aS)-1,4-difluoro-6'-methy...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 79 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM50129270 (CHEMBL3629740 | US9464103, (6aR,7S,10aS)-10a-(4-ch...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 228 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM250503 (US9464103, (6'R,6aR,7r,10aS)-1,4-difluoro-6'-methy...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 397 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human)) | BDBM250502 (US9464103, (6'R,6aR,7r,10aS)-10a-(4-chlorobenz...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 421 | n/a | n/a | n/a | n/a | 7.0 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ | |||||||||||
More data for this Ligand-Target Pair |