Compile Data Set for Download or QSAR

Found 32 hits of ic50 for UniProtKB: P27694   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461292 (US10774063, Compound NG-01-24) Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(I)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C24H21ClIN3O4/c1-33-17-10-7-15-11-18(24(25)27-19(15)12-17)21-13-20(14-5-8-16(26)9-6-14)28-29(21)22(30)3-2-4-23(31)32/h5-12,21H,2-4,13H2,1H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461287 (US10774063, Compound NG-01-25 | US10774063, Compou...) Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(I)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C26H25ClIN3O4/c1-2-35-19-12-9-17-13-20(26(27)29-21(17)14-19)23-15-22(16-7-10-18(28)11-8-16)30-31(23)24(32)5-3-4-6-25(33)34/h7-14,23H,2-6,15H2,1H3,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM260646 (US9533969, TDRL-505) Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C24H21BrClN3O4/c1-2-33-17-8-5-15-11-18(24(26)27-19(15)12-17)21-13-20(14-3-6-16(25)7-4-14)28-29(21)22(30)9-10-23(31)32/h3-8,11-12,21H,2,9-10,13H2,1H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	1.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed...				US Patent US9533969 (2017) BindingDB Entry DOI: 10.7270/Q2445KDJ
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461289 (US10774063, Compound TDRL-652) Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3cccc(I)c3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C26H25ClIN3O4/c1-2-35-19-11-10-17-13-20(26(27)29-21(17)14-19)23-15-22(16-6-5-7-18(28)12-16)30-31(23)24(32)8-3-4-9-25(33)34/h5-7,10-14,23H,2-4,8-9,15H2,1H3,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461287 (US10774063, Compound NG-01-25 | US10774063, Compou...) Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(I)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C26H25ClIN3O4/c1-2-35-19-12-9-17-13-20(26(27)29-21(17)14-19)23-15-22(16-7-10-18(28)11-8-16)30-31(23)24(32)5-3-4-6-25(33)34/h7-14,23H,2-6,15H2,1H3,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM61188 (4-[5-(4-methylphenyl)-3-[3-(4-methylphenyl)-1-phen...) Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1cn(nc1-c1ccc(C)cc1)-c1ccccc1)C(=O)CCC(O)=O |t:8| Show InChI InChI=1S/C30H28N4O3/c1-20-8-12-22(13-9-20)26-18-27(34(31-26)28(35)16-17-29(36)37)25-19-33(24-6-4-3-5-7-24)32-30(25)23-14-10-21(2)11-15-23/h3-15,19,27H,16-18H2,1-2H3,(H,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed...				US Patent US9533969 (2017) BindingDB Entry DOI: 10.7270/Q2445KDJ
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461270 (US10774063, Compound TDRL-505 | US10774063, Compou...) Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C25H23BrClN3O4/c1-2-34-18-11-8-16-12-19(25(27)28-20(16)13-18)22-14-21(15-6-9-17(26)10-7-15)29-30(22)23(31)4-3-5-24(32)33/h6-13,22H,2-5,14H2,1H3,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461282 (US10774063, Compound TDRL-543) Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C26H25BrClN3O4/c1-2-35-19-12-9-17-13-20(26(28)29-21(17)14-19)23-15-22(16-7-10-18(27)11-8-16)30-31(23)24(32)5-3-4-6-25(33)34/h7-14,23H,2-6,15H2,1H3,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461288 (US10774063, Compound TDRL-557) Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(OC(F)(F)F)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C27H25ClF3N3O5/c1-2-38-19-12-9-17-13-20(26(28)32-21(17)14-19)23-15-22(16-7-10-18(11-8-16)39-27(29,30)31)33-34(23)24(35)5-3-4-6-25(36)37/h7-14,23H,2-6,15H2,1H3,(H,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461285 (US10774063, Compound TDRL-534) Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C25H23BrClN3O4/c1-34-18-11-8-16-12-19(25(27)28-20(16)13-18)22-14-21(15-6-9-17(26)10-7-15)29-30(22)23(31)4-2-3-5-24(32)33/h6-13,22H,2-5,14H2,1H3,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461270 (US10774063, Compound TDRL-505 | US10774063, Compou...) Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C25H23BrClN3O4/c1-2-34-18-11-8-16-12-19(25(27)28-20(16)13-18)22-14-21(15-6-9-17(26)10-7-15)29-30(22)23(31)4-3-5-24(32)33/h6-13,22H,2-5,14H2,1H3,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461286 (US10774063, Compound TDRL-556) Show SMILES CC(C)Oc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:12| Show InChI InChI=1S/C27H27BrClN3O4/c1-16(2)36-20-12-9-18-13-21(27(29)30-22(18)14-20)24-15-23(17-7-10-19(28)11-8-17)31-32(24)25(33)5-3-4-6-26(34)35/h7-14,16,24H,3-6,15H2,1-2H3,(H,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461280 (US10774063, Compound TDRL-533) Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C24H21BrClN3O4/c1-33-17-10-7-15-11-18(24(26)27-19(15)12-17)21-13-20(14-5-8-16(25)9-6-14)28-29(21)22(30)3-2-4-23(31)32/h5-12,21H,2-4,13H2,1H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM260649 (US9533969, TDRL-522) Show SMILES Cc1ccc(cc1)-c1nn(cc1C1CC(=NN1C(=O)CCC(O)=O)c1ccc(Br)cc1)-c1ccccc1 |c:16| Show InChI InChI=1S/C29H25BrN4O3/c1-19-7-9-21(10-8-19)29-24(18-33(32-29)23-5-3-2-4-6-23)26-17-25(20-11-13-22(30)14-12-20)31-34(26)27(35)15-16-28(36)37/h2-14,18,26H,15-17H2,1H3,(H,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	5.61E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed...				US Patent US9533969 (2017) BindingDB Entry DOI: 10.7270/Q2445KDJ
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461276 (US10774063, Compound j) Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(Cl)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C24H21Cl2N3O4/c1-33-17-10-7-15-11-18(24(26)27-19(15)12-17)21-13-20(14-5-8-16(25)9-6-14)28-29(21)22(30)3-2-4-23(31)32/h5-12,21H,2-4,13H2,1H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM260648 (US9533969, TDRL-521) Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1cn(nc1-c1ccc(C)cc1)-c1ccccc1)C(=O)CCC(O)=O |t:9| Show InChI InChI=1S/C30H28N4O4/c1-20-8-10-22(11-9-20)30-25(19-33(32-30)23-6-4-3-5-7-23)27-18-26(21-12-14-24(38-2)15-13-21)31-34(27)28(35)16-17-29(36)37/h3-15,19,27H,16-18H2,1-2H3,(H,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed...				US Patent US9533969 (2017) BindingDB Entry DOI: 10.7270/Q2445KDJ
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461272 (US10774063, Compound f) Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCC(O)=O)c3ccc(Cl)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C23H19Cl2N3O4/c1-32-16-7-4-14-10-17(23(25)26-18(14)11-16)20-12-19(13-2-5-15(24)6-3-13)27-28(20)21(29)8-9-22(30)31/h2-7,10-11,20H,8-9,12H2,1H3,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	7.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461290 (US10774063, Compound NG-01-02) Show SMILES CCOc1ccc2cc(C3CC(=NN3c3cccc(c3)C(O)=O)c3ccc(I)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C27H21ClIN3O3/c1-2-35-21-11-8-17-13-22(26(28)30-23(17)14-21)25-15-24(16-6-9-19(29)10-7-16)31-32(25)20-5-3-4-18(12-20)27(33)34/h3-14,25H,2,15H2,1H3,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.55E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461271 (US10774063, Compound e) Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCC(O)=O)c3ccc(C)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C25H24ClN3O4/c1-3-33-18-9-8-17-12-19(25(26)27-20(17)13-18)22-14-21(16-6-4-15(2)5-7-16)28-29(22)23(30)10-11-24(31)32/h4-9,12-13,22H,3,10-11,14H2,1-2H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461281 (US10774063, Compound TDRL-540) Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(F)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C24H21ClFN3O4/c1-33-17-10-7-15-11-18(24(25)27-19(15)12-17)21-13-20(14-5-8-16(26)9-6-14)28-29(21)22(30)3-2-4-23(31)32/h5-12,21H,2-4,13H2,1H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461283 (US10774063, Compound TDRL-539) Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(F)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C25H23ClFN3O4/c1-34-18-11-8-16-12-19(25(26)28-20(16)13-18)22-14-21(15-6-9-17(27)10-7-15)29-30(22)23(31)4-2-3-5-24(32)33/h6-13,22H,2-5,14H2,1H3,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461269 (US10774063, Compound c) Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccccc1OC)C(=O)CCCC(O)=O |t:9| Show InChI InChI=1S/C22H24N2O5/c1-28-16-12-10-15(11-13-16)18-14-19(17-6-3-4-7-20(17)29-2)24(23-18)21(25)8-5-9-22(26)27/h3-4,6-7,10-13,19H,5,8-9,14H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461259 (US10774063, Compound b) Show SMILES COc1ccc(cc1OC)C1CC(=NN1C(=O)CCCC(O)=O)c1ccc(C)cc1 |c:13| Show InChI InChI=1S/C23H26N2O5/c1-15-7-9-16(10-8-15)18-14-19(17-11-12-20(29-2)21(13-17)30-3)25(24-18)22(26)5-4-6-23(27)28/h7-13,19H,4-6,14H2,1-3H3,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461255 (US10774063, Compound a) Show SMILES COc1ccc(cc1OC)C1CC(=NN1C(=O)CCCC(O)=O)c1ccccc1 |c:13| Show InChI InChI=1S/C22H24N2O5/c1-28-19-12-11-16(13-20(19)29-2)18-14-17(15-7-4-3-5-8-15)23-24(18)21(25)9-6-10-22(26)27/h3-5,7-8,11-13,18H,6,9-10,14H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM260650 (US9533969, TDRL-523) Show SMILES COc1ccc(cc1)-c1nn(cc1C1CC(=NN1C(=O)CCC(O)=O)c1ccc(Br)cc1)-c1ccccc1 |c:17| Show InChI InChI=1S/C29H25BrN4O4/c1-38-23-13-9-20(10-14-23)29-24(18-33(32-29)22-5-3-2-4-6-22)26-17-25(19-7-11-21(30)12-8-19)31-34(26)27(35)15-16-28(36)37/h2-14,18,26H,15-17H2,1H3,(H,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed...				US Patent US9533969 (2017) BindingDB Entry DOI: 10.7270/Q2445KDJ
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461291 (US10774063, Compound NG-01-04) Show SMILES CCOc1ccc2cc(C3CC(=NN3c3ccc(cc3)C(O)=O)c3ccc(I)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C27H21ClIN3O3/c1-2-35-21-12-7-18-13-22(26(28)30-23(18)14-21)25-15-24(16-3-8-19(29)9-4-16)31-32(25)20-10-5-17(6-11-20)27(33)34/h3-14,25H,2,15H2,1H3,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent									US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM260647 (US9533969, TDRL-518) Show SMILES CCN(CC)c1ccc(cc1)C1CC(=NN1C(=O)CCC(O)=O)c1ccc(Br)cc1 |c:14| Show InChI InChI=1S/C23H26BrN3O3/c1-3-26(4-2)19-11-7-17(8-12-19)21-15-20(16-5-9-18(24)10-6-16)25-27(21)22(28)13-14-23(29)30/h5-12,21H,3-4,13-15H2,1-2H3,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed...				US Patent US9533969 (2017) BindingDB Entry DOI: 10.7270/Q2445KDJ
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461273 (US10774063, Compound g) Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1cc2ccc(OC)cc2nc1Cl)C(=O)CCC(O)=O |t:9| Show InChI InChI=1S/C24H22ClN3O5/c1-32-16-6-3-14(4-7-16)20-13-21(28(27-20)22(29)9-10-23(30)31)18-11-15-5-8-17(33-2)12-19(15)26-24(18)25/h3-8,11-12,21H,9-10,13H2,1-2H3,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461278 (US10774063, Compound l) Show SMILES OC(=O)CCCC(=O)N1N=C(CC1c1cc2cc3OCCOc3cc2nc1Cl)c1ccccc1 |c:9| Show InChI InChI=1S/C25H22ClN3O5/c26-25-17(11-16-12-21-22(14-18(16)27-25)34-10-9-33-21)20-13-19(15-5-2-1-3-6-15)28-29(20)23(30)7-4-8-24(31)32/h1-3,5-6,11-12,14,20H,4,7-10,13H2,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461275 (US10774063, Compound i) Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(C)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C25H24ClN3O4/c1-15-6-8-16(9-7-15)21-14-22(29(28-21)23(30)4-3-5-24(31)32)19-12-17-10-11-18(33-2)13-20(17)27-25(19)26/h6-13,22H,3-5,14H2,1-2H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461274 (US10774063, Compound h) Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCC(O)=O)c3ccc(OC)c(OC)c3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C25H24ClN3O6/c1-33-16-6-4-14-10-17(25(26)27-18(14)12-16)20-13-19(28-29(20)23(30)8-9-24(31)32)15-5-7-21(34-2)22(11-15)35-3/h4-7,10-12,20H,8-9,13H2,1-3H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM461277 (US10774063, Compound k) Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(OC)c(OC)c3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C26H26ClN3O6/c1-34-17-9-7-15-11-18(26(27)28-19(15)13-17)21-14-20(16-8-10-22(35-2)23(12-16)36-3)29-30(21)24(31)5-4-6-25(32)33/h7-13,21H,4-6,14H2,1-3H3,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ...				US Patent US10774063 (2020) BindingDB Entry DOI: 10.7270/Q21N8479
					More data for this Ligand-Target Pair