Compile Data Set for Download or QSAR

Found 1686 hits of ic50 for UniProtKB: Q13370   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229805 (CHEMBL327234) Show SMILES Oc1nc2cc3cc(OCCCCC(=O)N4CCN(CC5CCCCC5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C26H35N5O3/c32-24(31-13-11-30(12-14-31)18-19-6-2-1-3-7-19)8-4-5-15-34-21-9-10-22-20(16-21)17-23-25(27-22)29-26(33)28-23/h9-10,16-17,19H,1-8,11-15,18H2,(H2,27,28,29,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229826 (CHEMBL88787) Show SMILES Oc1nc2cc3cc(OCCCCC(=O)N4CCN(Cc5ccccc5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C26H29N5O3/c32-24(31-13-11-30(12-14-31)18-19-6-2-1-3-7-19)8-4-5-15-34-21-9-10-22-20(16-21)17-23-25(27-22)29-26(33)28-23/h1-3,6-7,9-10,16-17H,4-5,8,11-15,18H2,(H2,27,28,29,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229833 (CHEMBL90877) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC5CCCCCC5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C26H35N5O3/c32-24(31-13-11-30(12-14-31)18-19-6-3-1-2-4-7-19)8-5-15-34-21-9-10-22-20(16-21)17-23-25(27-22)29-26(33)28-23/h9-10,16-17,19H,1-8,11-15,18H2,(H2,27,28,29,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229803 (CHEMBL329173) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CCC5CCCCC5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C26H35N5O3/c32-24(31-14-12-30(13-15-31)11-10-19-5-2-1-3-6-19)7-4-16-34-21-8-9-22-20(17-21)18-23-25(27-22)29-26(33)28-23/h8-9,17-19H,1-7,10-16H2,(H2,27,28,29,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM50532267 (CHEMBL131355) Show SMILES CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(I)c3)C(=O)CCC2)cc1 |c:6,14| Show InChI InChI=1S/C24H24IN3O2/c1-15-12-23(30)27-28-24(15)17-8-10-19(11-9-17)26-21-6-3-7-22(29)20(21)14-16-4-2-5-18(25)13-16/h2,4-5,8-11,13,15,26H,3,6-7,12,14H2,1H3,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Inhibition of human His-tagged PDE3B catalytic domain expressed in Escherichia coli BL21(DE3) pLysS cells				J Med Chem 59: 7029-65 (2016) Article DOI: 10.1021/acs.jmedchem.5b01813 BindingDB Entry DOI: 10.7270/Q2RX9GJ4
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM50532267 (CHEMBL131355) Show SMILES CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(I)c3)C(=O)CCC2)cc1 |c:6,14| Show InChI InChI=1S/C24H24IN3O2/c1-15-12-23(30)27-28-24(15)17-8-10-19(11-9-17)26-21-6-3-7-22(29)20(21)14-16-4-2-5-18(25)13-16/h2,4-5,8-11,13,15,26H,3,6-7,12,14H2,1H3,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Inhibition of human His-tagged PDE3B catalytic domain expressed in Escherichia coli BL21(DE3) pLysS cells				J Med Chem 59: 7029-65 (2016) Article DOI: 10.1021/acs.jmedchem.5b01813 BindingDB Entry DOI: 10.7270/Q2RX9GJ4
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50000927 (CHEMBL88108 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...) Show SMILES OC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1 Show InChI InChI=1S/C22H26N4O5/c27-19(26(13-20(28)29)15-5-2-1-3-6-15)7-4-10-31-16-8-9-17-14(11-16)12-18-21(23-17)25-22(30)24-18/h8-9,11-12,15H,1-7,10,13H2,(H,28,29)(H2,23,24,25,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229802 (CHEMBL328543) Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1 Show InChI InChI=1S/C23H29N5O5/c1-23(2,3)33-22(31)28-10-8-27(9-11-28)19(29)5-4-12-32-16-6-7-17-15(13-16)14-18-20(24-17)26-21(30)25-18/h6-7,13-14H,4-5,8-12H2,1-3H3,(H2,24,25,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229806 (CHEMBL91503) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CCc5ccccc5C(F)(F)F)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C27H28F3N5O3/c28-27(29,30)21-5-2-1-4-18(21)9-10-34-11-13-35(14-12-34)24(36)6-3-15-38-20-7-8-22-19(16-20)17-23-25(31-22)33-26(37)32-23/h1-2,4-5,7-8,16-17H,3,6,9-15H2,(H2,31,32,33,37)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229804 (CHEMBL90647) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC4)C(c4ccc(F)cc4)c4ccc(F)cc4)ccc3[nH]c2n1 Show InChI InChI=1S/C31H29F2N5O3/c32-23-7-3-20(4-8-23)29(21-5-9-24(33)10-6-21)38-15-13-37(14-16-38)28(39)2-1-17-41-25-11-12-26-22(18-25)19-27-30(34-26)36-31(40)35-27/h3-12,18-19,29H,1-2,13-17H2,(H2,34,35,36,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229821 (CHEMBL91388) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5ccc(cc5)C(F)(F)F)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C26H26F3N5O3/c27-26(28,29)19-5-3-17(4-6-19)16-33-9-11-34(12-10-33)23(35)2-1-13-37-20-7-8-21-18(14-20)15-22-24(30-21)32-25(36)31-22/h3-8,14-15H,1-2,9-13,16H2,(H2,30,31,32,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229792 (CHEMBL329788) Show SMILES CCCC(CCC)CN1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1 Show InChI InChI=1S/C26H37N5O3/c1-3-6-19(7-4-2)18-30-11-13-31(14-12-30)24(32)8-5-15-34-21-9-10-22-20(16-21)17-23-25(27-22)29-26(33)28-23/h9-10,16-17,19H,3-8,11-15,18H2,1-2H3,(H2,27,28,29,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50000915 (5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...) Show SMILES CN(C1CCCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1 Show InChI InChI=1S/C23H30N4O3/c1-27(17-8-4-2-3-5-9-17)21(28)10-6-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)26-23(29)25-20/h11-12,14-15,17H,2-10,13H2,1H3,(H2,24,25,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229764 (CHEMBL432057) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC5CCCCC5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C25H33N5O3/c31-23(30-12-10-29(11-13-30)17-18-5-2-1-3-6-18)7-4-14-33-20-8-9-21-19(15-20)16-22-24(26-21)28-25(32)27-22/h8-9,15-16,18H,1-7,10-14,17H2,(H2,26,27,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50000900 (CHEMBL90804 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...) Show SMILES COC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1 Show InChI InChI=1S/C23H28N4O5/c1-31-21(29)14-27(16-6-3-2-4-7-16)20(28)8-5-11-32-17-9-10-18-15(12-17)13-19-22(24-18)26-23(30)25-19/h9-10,12-13,16H,2-8,11,14H2,1H3,(H2,24,25,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229814 (CHEMBL92165) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC5CCCC5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C24H31N5O3/c30-22(29-11-9-28(10-12-29)16-17-4-1-2-5-17)6-3-13-32-19-7-8-20-18(14-19)15-21-23(25-20)27-24(31)26-21/h7-8,14-15,17H,1-6,9-13,16H2,(H2,25,26,27,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229771 (CHEMBL91088) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC4)c4cccc(c4)C(F)(F)F)ccc3[nH]c2n1 Show InChI InChI=1S/C25H24F3N5O3/c26-25(27,28)17-3-1-4-18(15-17)32-8-10-33(11-9-32)22(34)5-2-12-36-19-6-7-20-16(13-19)14-21-23(29-20)31-24(35)30-21/h1,3-4,6-7,13-15H,2,5,8-12H2,(H2,29,30,31,35)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229788 (CHEMBL91715) Show SMILES Oc1nc2cc3cc(OCCCCCC(=O)N4CCN(CC5CCCCC5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C27H37N5O3/c33-25(32-14-12-31(13-15-32)19-20-7-3-1-4-8-20)9-5-2-6-16-35-22-10-11-23-21(17-22)18-24-26(28-23)30-27(34)29-24/h10-11,17-18,20H,1-9,12-16,19H2,(H2,28,29,30,34)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50231553 (CHEMBL1203032) Show SMILES Cl.Oc1nc2cc3cc(OCCCS(=O)(=O)C4CCN(Cc5ccccc5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C25H28N4O4S/c30-25-27-23-16-19-15-20(7-8-22(19)26-24(23)28-25)33-13-4-14-34(31,32)21-9-11-29(12-10-21)17-18-5-2-1-3-6-18/h1-3,5-8,15-16,21H,4,9-14,17H2,(H2,26,27,28,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.630	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet aggregation cAMP PDE in vitro				J Med Chem 36: 3251-64 (1993) Article DOI: 10.1021/jm00074a005 BindingDB Entry DOI: 10.7270/Q289184P
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229770 (CHEMBL433183) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5ccccc5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C25H27N5O3/c31-23(30-12-10-29(11-13-30)17-18-5-2-1-3-6-18)7-4-14-33-20-8-9-21-19(15-20)16-22-24(26-21)28-25(32)27-22/h1-3,5-6,8-9,15-16H,4,7,10-14,17H2,(H2,26,27,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229791 (CHEMBL330086) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5ccsc5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C23H25N5O3S/c29-21(28-8-6-27(7-9-28)14-16-5-11-32-15-16)2-1-10-31-18-3-4-19-17(12-18)13-20-22(24-19)26-23(30)25-20/h3-5,11-13,15H,1-2,6-10,14H2,(H2,24,25,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229790 (CHEMBL329573) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC5CCCCO5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C24H31N5O4/c30-22(29-10-8-28(9-11-29)16-19-4-1-2-12-33-19)5-3-13-32-18-6-7-20-17(14-18)15-21-23(25-20)27-24(31)26-21/h6-7,14-15,19H,1-5,8-13,16H2,(H2,25,26,27,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229830 (CHEMBL90876) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5cccs5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C23H25N5O3S/c29-21(28-9-7-27(8-10-28)15-18-3-2-12-32-18)4-1-11-31-17-5-6-19-16(13-17)14-20-22(24-19)26-23(30)25-20/h2-3,5-6,12-14H,1,4,7-11,15H2,(H2,24,25,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229796 (CHEMBL431085) Show SMILES Oc1nc2cc3cc(OCCCC(=O)NC4CCN(Cc5ccccc5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C26H29N5O3/c32-24(27-20-10-12-31(13-11-20)17-18-5-2-1-3-6-18)7-4-14-34-21-8-9-22-19(15-21)16-23-25(28-22)30-26(33)29-23/h1-3,5-6,8-9,15-16,20H,4,7,10-14,17H2,(H,27,32)(H2,28,29,30,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50231339 (CHEMBL1203039) Show SMILES Cl.CCC(CC)CN1CCC(CC1)n1nnnc1CCCOc1ccc2[nH]c3nc(O)nc3cc2c1 Show InChI InChI=1S/C25H34N8O2/c1-3-17(4-2)16-32-11-9-19(10-12-32)33-23(29-30-31-33)6-5-13-35-20-7-8-21-18(14-20)15-22-24(26-21)28-25(34)27-22/h7-8,14-15,17,19H,3-6,9-13,16H2,1-2H3,(H2,26,27,28,34)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet aggregation cAMP PDE in vitro				J Med Chem 36: 3251-64 (1993) Article DOI: 10.1021/jm00074a005 BindingDB Entry DOI: 10.7270/Q289184P
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50231400 (CHEMBL1203053) Show SMILES Cl.Oc1nc2cc3cc(OCCCc4nnnn4C4CCN(CC5CCCCC5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C26H34N8O2/c35-26-28-23-16-19-15-21(8-9-22(19)27-25(23)29-26)36-14-4-7-24-30-31-32-34(24)20-10-12-33(13-11-20)17-18-5-2-1-3-6-18/h8-9,15-16,18,20H,1-7,10-14,17H2,(H2,27,28,29,35)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet aggregation cAMP PDE in vitro				J Med Chem 36: 3251-64 (1993) Article DOI: 10.1021/jm00074a005 BindingDB Entry DOI: 10.7270/Q289184P
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50231552 (CHEMBL1203031) Show SMILES Cl.Oc1nc2cc3cc(OCCCc4nnnn4C4CCN(Cc5ccccc5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C26H28N8O2/c35-26-28-23-16-19-15-21(8-9-22(19)27-25(23)29-26)36-14-4-7-24-30-31-32-34(24)20-10-12-33(13-11-20)17-18-5-2-1-3-6-18/h1-3,5-6,8-9,15-16,20H,4,7,10-14,17H2,(H2,27,28,29,35)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet aggregation cAMP PDE in vitro				J Med Chem 36: 3251-64 (1993) Article DOI: 10.1021/jm00074a005 BindingDB Entry DOI: 10.7270/Q289184P
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229768 (CHEMBL91014) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5ccc6OCOc6c5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C26H27N5O5/c32-24(31-9-7-30(8-10-31)15-17-3-6-22-23(12-17)36-16-35-22)2-1-11-34-19-4-5-20-18(13-19)14-21-25(27-20)29-26(33)28-21/h3-6,12-14H,1-2,7-11,15-16H2,(H2,27,28,29,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229766 (CHEMBL91249) Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC4)C4CCCCCC4)ccc3[nH]c2n1 Show InChI InChI=1S/C25H33N5O3/c31-23(30-13-11-29(12-14-30)19-6-3-1-2-4-7-19)8-5-15-33-20-9-10-21-18(16-20)17-22-24(26-21)28-25(32)27-22/h9-10,16-17,19H,1-8,11-15H2,(H2,26,27,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50226700 (CHEMBL326891) Show SMILES O=C(CCN(C1CCCCC1)C(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1)Oc1ccccc1 |t:22| Show InChI InChI=1S/C29H34N4O5/c34-26-20-32-19-21-18-24(13-14-25(21)30-29(32)31-26)37-17-7-12-27(35)33(22-8-3-1-4-9-22)16-15-28(36)38-23-10-5-2-6-11-23/h2,5-6,10-11,13-14,18,22H,1,3-4,7-9,12,15-17,19-20H2,(H,30,31,34)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.940	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibition of cyclic AMP phosphodiesterase from human platelets				J Med Chem 30: 303-18 (1987) BindingDB Entry DOI: 10.7270/Q27946X0
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50000933 (CHEMBL92264 | N-Adamantan-1-yl-4-(2-oxo-2,3-dihydr...) Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:28:23:30:27.29.26,28:27:30:23.22.24| Show InChI InChI=1S/C24H28N4O3/c29-21(28-24-11-14-6-15(12-24)8-16(7-14)13-24)2-1-5-31-18-3-4-19-17(9-18)10-20-22(25-19)27-23(30)26-20/h3-4,9-10,14-16H,1-2,5-8,11-13H2,(H,28,29)(H2,25,26,27,30)/t14-,15+,16-,24?	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229762 (CHEMBL313021) Show SMILES CCC(CC)CN1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1 Show InChI InChI=1S/C24H33N5O3/c1-3-17(4-2)16-28-9-11-29(12-10-28)22(30)6-5-13-32-19-7-8-20-18(14-19)15-21-23(25-20)27-24(31)26-21/h7-8,14-15,17H,3-6,9-13,16H2,1-2H3,(H2,25,26,27,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50226571 (CHEMBL108876) Show SMILES CC(C)(C)OC(=O)CCN(C1CCCCC1)C(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1 |t:27| Show InChI InChI=1S/C27H38N4O5/c1-27(2,3)36-25(34)13-14-31(20-8-5-4-6-9-20)24(33)10-7-15-35-21-11-12-22-19(16-21)17-30-18-23(32)29-26(30)28-22/h11-12,16,20H,4-10,13-15,17-18H2,1-3H3,(H,28,29,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against sigma receptor				J Med Chem 30: 303-18 (1987) BindingDB Entry DOI: 10.7270/Q27946X0
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50226561 (CHEMBL321600) Show SMILES CN(C1CCCCCC1)C(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1 |t:20| Show InChI InChI=1S/C22H30N4O3/c1-25(17-7-4-2-3-5-8-17)21(28)9-6-12-29-18-10-11-19-16(13-18)14-26-15-20(27)24-22(26)23-19/h10-11,13,17H,2-9,12,14-15H2,1H3,(H,23,24,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperone				J Med Chem 30: 303-18 (1987) BindingDB Entry DOI: 10.7270/Q27946X0
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50000909 (7-(4-Benzenesulfonyl-butoxy)-1,3-dihydro-imidazo[4...) Show SMILES O=c1[nH]c2cc3cc(OCCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1 Show InChI InChI=1S/C20H19N3O4S/c24-20-22-18-13-14-12-15(8-9-17(14)21-19(18)23-20)27-10-4-5-11-28(25,26)16-6-2-1-3-7-16/h1-3,6-9,12-13H,4-5,10-11H2,(H2,21,22,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50231396 (CHEMBL1203034) Show SMILES Cl.Oc1nc2cc3cc(OCCCc4nnnn4C4CCN(Cc5ccc(F)cc5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C26H27FN8O2/c27-19-5-3-17(4-6-19)16-34-11-9-20(10-12-34)35-24(31-32-33-35)2-1-13-37-21-7-8-22-18(14-21)15-23-25(28-22)30-26(36)29-23/h3-8,14-15,20H,1-2,9-13,16H2,(H2,28,29,30,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet aggregation cAMP PDE in vitro				J Med Chem 36: 3251-64 (1993) Article DOI: 10.1021/jm00074a005 BindingDB Entry DOI: 10.7270/Q289184P
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229794 (CHEMBL90176) Show SMILES CC(C)CN1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1 Show InChI InChI=1S/C22H29N5O3/c1-15(2)14-26-7-9-27(10-8-26)20(28)4-3-11-30-17-5-6-18-16(12-17)13-19-21(23-18)25-22(29)24-19/h5-6,12-13,15H,3-4,7-11,14H2,1-2H3,(H2,23,24,25,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50231546 (CHEMBL1203024) Show SMILES Cl.Oc1nc2cc3cc(OCCCS(=O)(=O)C4CCN(CC5CCCCC5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C25H34N4O4S/c30-25-27-23-16-19-15-20(7-8-22(19)26-24(23)28-25)33-13-4-14-34(31,32)21-9-11-29(12-10-21)17-18-5-2-1-3-6-18/h7-8,15-16,18,21H,1-6,9-14,17H2,(H2,26,27,28,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet aggregation cAMP PDE in vitro				J Med Chem 36: 3251-64 (1993) Article DOI: 10.1021/jm00074a005 BindingDB Entry DOI: 10.7270/Q289184P
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50231537 (CHEMBL1203019) Show SMILES Cl.Oc1nc2cc3cc(OCCCNC(=O)N4CCN(CC5CCCCC5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C25H34N6O3/c32-24-28-22-16-19-15-20(7-8-21(19)27-23(22)29-24)34-14-4-9-26-25(33)31-12-10-30(11-13-31)17-18-5-2-1-3-6-18/h7-8,15-16,18H,1-6,9-14,17H2,(H,26,33)(H2,27,28,29,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet aggregation cAMP PDE in vitro				J Med Chem 36: 3251-64 (1993) Article DOI: 10.1021/jm00074a005 BindingDB Entry DOI: 10.7270/Q289184P
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50231560 (CHEMBL1203083) Show SMILES Cl.Oc1nc2cc3cc(OCCCNC(=O)N4CCN(Cc5ccccc5)CC4)ccc3[nH]c2n1 Show InChI InChI=1S/C25H28N6O3/c32-24-28-22-16-19-15-20(7-8-21(19)27-23(22)29-24)34-14-4-9-26-25(33)31-12-10-30(11-13-31)17-18-5-2-1-3-6-18/h1-3,5-8,15-16H,4,9-14,17H2,(H,26,33)(H2,27,28,29,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet aggregation cAMP PDE in vitro				J Med Chem 36: 3251-64 (1993) Article DOI: 10.1021/jm00074a005 BindingDB Entry DOI: 10.7270/Q289184P
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50231551 (CHEMBL1203086) Show SMILES Cl.CCC(CC)CN1CCC(CC1)S(=O)(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1 Show InChI InChI=1S/C24H34N4O4S/c1-3-17(4-2)16-28-10-8-20(9-11-28)33(30,31)13-5-12-32-19-6-7-21-18(14-19)15-22-23(25-21)27-24(29)26-22/h6-7,14-15,17,20H,3-5,8-13,16H2,1-2H3,(H2,25,26,27,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet aggregation cAMP PDE in vitro				J Med Chem 36: 3251-64 (1993) Article DOI: 10.1021/jm00074a005 BindingDB Entry DOI: 10.7270/Q289184P
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50226691 (CHEMBL109149) Show SMILES CC(C)OC(=O)CCN(C1CCCCC1)C(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1 |t:26| Show InChI InChI=1S/C26H36N4O5/c1-18(2)35-25(33)12-13-30(20-7-4-3-5-8-20)24(32)9-6-14-34-21-10-11-22-19(15-21)16-29-17-23(31)28-26(29)27-22/h10-11,15,18,20H,3-9,12-14,16-17H2,1-2H3,(H,27,28,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibition of cyclic AMP phosphodiesterase from human platelets				J Med Chem 30: 303-18 (1987) BindingDB Entry DOI: 10.7270/Q27946X0
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50231511 (CHEMBL1203063) Show SMILES Cl.CCC(CC)CN1CCN(CC1)C(=O)NCCCOc1ccc2[nH]c3nc(O)nc3cc2c1 Show InChI InChI=1S/C24H34N6O3/c1-3-17(4-2)16-29-9-11-30(12-10-29)24(32)25-8-5-13-33-19-6-7-20-18(14-19)15-21-22(26-20)28-23(31)27-21/h6-7,14-15,17H,3-5,8-13,16H2,1-2H3,(H,25,32)(H2,26,27,28,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet aggregation cAMP PDE in vitro				J Med Chem 36: 3251-64 (1993) Article DOI: 10.1021/jm00074a005 BindingDB Entry DOI: 10.7270/Q289184P
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50226565 (CHEMBL324011) Show SMILES COCCN(C1CCCCC1)C(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1 |t:22| Show InChI InChI=1S/C23H32N4O4/c1-30-13-11-27(18-6-3-2-4-7-18)22(29)8-5-12-31-19-9-10-20-17(14-19)15-26-16-21(28)25-23(26)24-20/h9-10,14,18H,2-8,11-13,15-16H2,1H3,(H,24,25,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against sigma receptor				J Med Chem 30: 303-18 (1987) BindingDB Entry DOI: 10.7270/Q27946X0
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50226583 (CHEMBL110484) Show SMILES O=C(CCCOc1ccc2N=C3NC(=O)CN3Cc2c1)N(C1CCCCC1)C1CCCCC1 |t:10| Show InChI InChI=1S/C26H36N4O3/c31-24-18-29-17-19-16-22(13-14-23(19)27-26(29)28-24)33-15-7-12-25(32)30(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h13-14,16,20-21H,1-12,15,17-18H2,(H,27,28,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibition of cyclic AMP phosphodiesterase from human platelets				J Med Chem 30: 303-18 (1987) BindingDB Entry DOI: 10.7270/Q27946X0
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50226705 (CHEMBL106922) Show SMILES CCN(C1CCCCC1)C(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1 |t:20| Show InChI InChI=1S/C22H30N4O3/c1-2-26(17-7-4-3-5-8-17)21(28)9-6-12-29-18-10-11-19-16(13-18)14-25-15-20(27)24-22(25)23-19/h10-11,13,17H,2-9,12,14-15H2,1H3,(H,23,24,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibition of cyclic AMP phosphodiesterase from human platelets				J Med Chem 30: 303-18 (1987) BindingDB Entry DOI: 10.7270/Q27946X0
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50226674 (CHEMBL107651) Show SMILES COC(=O)CCN(C1CCCCC1)C(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1 |t:24| Show InChI InChI=1S/C24H32N4O5/c1-32-23(31)11-12-28(18-6-3-2-4-7-18)22(30)8-5-13-33-19-9-10-20-17(14-19)15-27-16-21(29)26-24(27)25-20/h9-10,14,18H,2-8,11-13,15-16H2,1H3,(H,25,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibition of cyclic AMP phosphodiesterase from human platelets				J Med Chem 30: 303-18 (1987) BindingDB Entry DOI: 10.7270/Q27946X0
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50226618 (CHEMBL106201) Show SMILES O=C(CCCOc1ccc2N=C3NC(=O)CN3Cc2c1)C(CC1CCCCN1)(C1CCCCC1)C1CCCCC1 |t:10| Show InChI InChI=1S/C33H48N4O3/c38-30(15-9-19-40-28-16-17-29-24(20-28)22-37-23-31(39)36-32(37)35-29)33(25-10-3-1-4-11-25,26-12-5-2-6-13-26)21-27-14-7-8-18-34-27/h16-17,20,25-27,34H,1-15,18-19,21-23H2,(H,35,36,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vivo inhibition of cyclic AMP phosphodiesterase from human platelets				J Med Chem 30: 303-18 (1987) BindingDB Entry DOI: 10.7270/Q27946X0
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50000868 (CHEMBL88444 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...) Show SMILES CCOC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1 Show InChI InChI=1S/C24H30N4O5/c1-2-32-22(30)15-28(17-7-4-3-5-8-17)21(29)9-6-12-33-18-10-11-19-16(13-18)14-20-23(25-19)27-24(31)26-20/h10-11,13-14,17H,2-9,12,15H2,1H3,(H2,25,26,27,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50229765 (CHEMBL89810) Show SMILES CCOC(=O)CN1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1 Show InChI InChI=1S/C22H27N5O5/c1-2-31-20(29)14-26-7-9-27(10-8-26)19(28)4-3-11-32-16-5-6-17-15(12-16)13-18-21(23-17)25-22(30)24-18/h5-6,12-13H,2-4,7-11,14H2,1H3,(H2,23,24,25,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet c-AMP phosphodiesterase PDE 3				J Med Chem 35: 2688-96 (1992) BindingDB Entry DOI: 10.7270/Q2PN97WB
					More data for this Ligand-Target Pair

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